Mattison was a non-participant at Wednesday's practice due to a shoulder injury.

EDGE Analysis

Mattison has filled in admirably for Dalvin Cook (ankle) during recent absences in Weeks 3 and 5, racking up at least 150 yards from scrimmage on both occasions and recording a receiving touchdown in the latter contest. Now, Mattison seems to be less healthy than Cook, as he didn't do more than take part in stretching before heading indoors at the start of practice Wednesday, according to Courtney Cronin of ESPN.com. As for Cook, he officially was limited to begin Week 6 prep, so this situation bears monitoring as the week goes on to get a bearing on who among the two will be available Sunday in Carolina.

Mattison rushed 25 times for 113 yards while hauling in seven passes for 40 yards and a touchdown in Sunday's 19-17 win over the Lions.

EDGE Analysis

Mattison got another spot start in place of Dalvin Cook (ankle) and did his best impression of the star back. This was the second start the backup received this season, and he provided nearly an identical stat line against the Seahawks in Week 3. Cook's status for next week's tilt against the Panthers is unclear, but Mattison is proving to be a capable fantasy producer when called upon this year. That being said, Carolina provides a much tougher matchup compared to the two defenses Mattison ran all over in his two starts to date.

Mattison will be the Vikings' lead running back Sunday versus the Lions with Dalvin Cook (ankle) inactive, Courtney Cronin of ESPN.com reports.

EDGE Analysis

This will mark Mattison's second spot start of the campaign in place of Cook. In Week 3, Mattison was a workhorse against the Seahawks, turning 26 carries into 112 yards and six catches (on eight targets) into 59 yards. He has a good matchup on tap in which to produce this time around, too, as Detroit's defense has given up 134.8 yards from scrimmage per game and nine total TDs to running backs in four contests this season.

Mattison rushed 10 times for 20 yards and didn't draw a target in the Vikings' 14-7 loss to the Browns on Sunday.

EDGE Analysis

Dalvin Cook was active and logged nine carries along with six targets, so he was more involved overall than Mattison. However, Mattison did pace the duo in rushing workload, a development that may well have been tied to Cook playing on an ankle that still wasn't 100 percent after only a one-week absence. Mattison could well return to his more customary complementary role in a Week 5 home matchup versus the Lions.

Mattison is expected to serve as the Vikings' No. 2 option out of the backfield Sunday against the Browns with Dalvin Cook (ankle) considered likely to play after missing Minnesota's Week 3 win over the Seahawks, Adam Schefter of ESPN reports.

EDGE Analysis

Cook was a limited participant in practice throughout the week and remains listed as questionable for the contest, but he's expected to avoid the inactive list, which the Vikings will release 90 minutes prior to the 1 p.m. ET kickoff. Assuming that's the case, Cook should take back starting duties for the Vikings, though he could handle a lighter workload than normal if Minnesota is keen on easing him back in from the ankle injury. With that in mind, Mattison doesn't look like a bankable fantasy option if Cook is active, even though the Boise State product is coming off an impressive Week 3 outing in which he finished with 112 yards on 26 carries and 59 yards on six receptions.

Mattison carried the ball 26 times for 112 yards and caught six of eight targets for 59 yards in Sunday's 30-17 win over the Seahawks.

EDGE Analysis

With Dalvin Cook (ankle) sidelined, Mattison stepped into the lead role in the Minnesota backfield and put up a very Cook-like performance, proving to be effective as both a runner and receiver. The third-year back is more than capable of delivering big numbers when called upon, but his fantasy value will depend on Cook's health heading into a Week 4 clash with the Browns.

Mattison is starting in place of Dalvin Cook (ankle) on Sunday against the Seahawks, Eric Smith of the Vikings' official site reports.

EDGE Analysis

Cook will sit at least one game due to the ankle sprain he picked up Week 2, allowing Mattison a spot start. When Cook went down with a groin injury Week 5 of last season in Seattle, Mattison put together the only 100-yard rushing performance of his career, totaling 112 yards on the ground and 24 more yards as a receiver. With just Ameer Abdullah and fullback C.J. Ham to contend with for touches, Mattison could be poised for another fruitful outing Sunday.

Mattison could have a big opportunity Sunday, as the Vikings are pessimistic about Dalvin Cook (questionable - ankle) suiting up for their game against the Seahawks, Ian Rapoport of NFL Network reports.

EDGE Analysis

Cook is a game-day decision and could have a limited role even if he's active. Last year, Mattison had one dud (Week 6) and one huge performance (Week 17) in his two fill-in starts, and he should handle a large workload Sunday if Cook doesn't end up playing. Ameer Abdullah is the only other tailback on Minnesota's roster for Sunday's game, with the team opting not to call up preseason star A.J. Rose from the practice squad.

Mattison had three carries for 11 yards and one reception for 17 yards on his only target in Sunday's loss to Arizona.

EDGE Analysis

Mattison played 13 snaps on offense, slightly up from nine snaps last week, but he had four touches compared to two last week. He'll have a minimal role as long as Dalvin Cook is healthy. However, Mattison's workload could increase Week 3 if the sprained ankle that Cook suffered Sunday limits his snaps.

Mattison had one carry for two yards and one reception for four yards in Sunday's loss at Cincinnati.

EDGE Analysis

Mattison played just nine snaps on offense as the Vikings used the running game sparingly when falling behind early. Mattison may get more involved if the Vikings are ahead and running the ball more often, but he won't get significant touches without a Dalvin Cook injury.