Isaac Guerendo
RB SF (14)
Mon 9/15/25 2:18 PM

Guerendo returned two kickoffs for 47 yards and was not used on offense in Sunday's 26-21 win over the Saints.
EDGE Analysis
Guerendo failed to see the field on offense Sunday, logging all 17 of his snaps on special teams. Veteran backup Brian Robinson continues to handle all of the touches starter Christian McCaffrey doesn't gobble up on game days. More of the same can be expected against the Cardinals in Week 3, leaving Guerendo off the fantasy radar until an injury opens up playing time for the sophomore.

Isaac Guerendo
RB SF (14)
Mon 9/8/25 2:59 PM

Guerendo played 15 snaps on special teams and did not receive a carry in Sunday's 17-13 win over the Seahawks.
EDGE Analysis
The good news for Guerendo was that he was fully cleared from the shoulder injury that limited him in camp. That bad news for the sophomore tailback is that new addition Brian Robinson usurped him on the depth chart. Guerendo dropped to third in the pecking order and was limited to special teams, returning one kickoff for 16 yards. In his current role, Guerendo provides no fantasy utility heading into next Sunday's tilt against the Saints.

Isaac Guerendo
RB SF (14)
Wed 9/3/25 7:04 PM

Guerendo (shoulder) practiced fully Wednesday, Cam Inman of The San Jose Mercury News reports.
EDGE Analysis
Guerendo exited practice on Aug. 2 due to a shoulder injury and sat out the next two-and-a-half weeks, only to be healthy enough to play in the 49ers' preseason finale Aug. 23 and turn eight carries into 13 yards and one catch (on one target) into one yard. In the midst of it all, the team traded for Commanders RB Brian Robinson, placing Guerendo's status into question heading into Week 1. Even though Guerendo has a clean bill of health in advance of Sunday's contest at Seattle, he may play third fiddle out of San Francisco's backfield to starter Christian McCaffrey and Robinson.

Isaac Guerendo
RB SF (14)
Sun 8/24/25 12:39 AM

Guerendo (shoulder) rushed the ball eight times for 13 yards in Saturday's 30-23 preseason win over the Chargers. He added one reception on one target for one yard.
EDGE Analysis
Guerendo started the game with Christian McCaffrey resting and Brian Robinson not yet officially with the team. Per Eric Branch of the San Francisco Chronicle, Guerendo appeared to aggravate the shoulder injury he suffered earlier in camp in the first quarter and was wearing a brace as protection. Positively, he was able to return to the game, so it appears as though he'll be available for San Francisco's Week 1 matchup against Seattle -- albeit with an unclear role.

Isaac Guerendo
RB SF (14)
Fri 8/22/25 12:41 PM1 Comment

Guerendo may open the season as San Francisco's No. 2 running back even though the team is trading for Brian Robinson, Cam Inman of The San Jose Mercury News reports.
EDGE Analysis
The 49ers presumably wouldn't trade for Robinson, even at the cost of just a sixth-round pick, unless they thought he could become their No. 2 running back. That doesn't mean he'll simply be handed the gig, however, nor does it mean he'll be comfortable with the playbook in time for Week 1 at Seattle. Still, the trade takes a chunk out of Guerendo's fantasy value, adding another legitimate competitor for backup roles after the Niners drafted Jordan James (finger) in the fifth round this spring. Guerendo is the fastest and most athletic of the bunch, but his injury history dating back to college is concerning, to say the least.

Isaac Guerendo
RB SF (14)
Tue 8/19/25 5:56 PM

Guerendo (shoulder) participated in Tuesday's training camp practice, Nick Wagoner of ESPN.com reports.
EDGE Analysis
Guerendo suffered a shoulder injury in practice in early August, which caused him to miss the 49ers' first two preseason games. He was back on the field Tuesday and was given the green light to participate in team drills, and Wagoner relays that Guerendo was heavily involved with the offense and on special teams as a kick returner. Barring any setbacks, the 2024 fourth-rounder is on track to be available for Saturday's preseason finale against the Chargers.

Isaac Guerendo
RB SF (14)
Mon 8/4/25 3:18 PM

49ers coach Kyle Shanahan said Monday that Guerendo (shoulder) is expected to miss a couple weeks, Matt Maiocco of NBC Sports Bay Area reports.
EDGE Analysis
Guerendo made an early exit from Saturday's practice and apparently won't be back for a while. It sounds like he has a chance to be ready for Week 1, but a preseason appearance probably isn't in the cards. Guerendo's absence could give rookie Jordan James more opportunities to mix in with the first-team offense, especially on days when Christian McCaffrey is rested.

Isaac Guerendo
RB SF (14)
Sat 8/2/25 3:46 PM

Guerendo had an early departure from practice Saturday due to an apparent shoulder injury, Jennifer Lee Chan of NBC Sports Bay Area reports.
EDGE Analysis
The possible injury occurred during special-teams drills. It's not yet clear how severe the issue may be, though that should become more evident once 49ers coach Kyle Shanahan chimes in and/or based on Guerendo's practice status in the days ahead. Guerendo is the favorite to work as San Francisco's No. 2 running back this season and should also see action as a kick returner.

Isaac Guerendo
RB SF (14)
Fri 6/6/25 12:14 PM

Guerendo (knee/ankle) was an active participant at voluntary OTAs, per the 49ers' official site.
EDGE Analysis
Guerendo sustained MCL and ankle sprains in his left leg during San Francisco's regular-season finale, but the 2024 fourth-round pick appears back to full health ahead of mandatory minicamp, which will take place June 10-11. Christian McCaffrey also looks fully healthy after having been limited to four appearances in 2024, which leaves Guerendo competing for No. 2 reps entering Year 2 of his career. The 49ers saw fit to trade Jordan Mason to Minnesota this offseason and let Elijah Mitchell link up with the Chiefs in free agency, though the team did re-sign Patrick Taylor and select Jordan James in the fifth round of the 2025 NFL Draft. Guerendo's combo of athleticism and explosiveness makes him a high-upside backup to McCaffrey, but injuries have been a consistent roadblock for him dating back to college.

Isaac Guerendo
RB SF (14)
Mon 1/6/25 8:10 PM

Guerendo has been diagnosed with MCL and ankle sprains in his left leg following an MRI on Monday, but he didn't damage the ACL in his left knee during Sunday's loss at Arizona, Matt Barrows of The Athletic reports.
EDGE Analysis
The 49ers' 2024 campaign is over, but the team's season finale included yet another RB injury. On only his second carry of Sunday's game, Guerendo had his left leg twisted under him as he was tackled, and he needed a cart to go to the locker room. He thus is one of four San Francisco running backs to enter the offseason focusing on rehab. The others are Christian McCaffrey (knee), Jordan Mason (ankle) and Elijah Mitchell (hamstring). Guerendo, a 2024 fourth-round pick, proved to be effective when given the chance as a rookie, turning 84 carries into 420 yards (5.0 YPC) and four touchdowns and hauling in 15 of 16 targets for 152 yards in 16 appearances.