Isaac Guerendo
RB SF (14)
Wed 1/7/26 8:53 PM

Guerendo was only utilized on special teams this season, finishing with 100 kick return yards across 14 active games.
EDGE Analysis
Guerendo entered his sophomore campaign with an opportunity to serve as Christian McCaffrey's primary backup, but he failed to seize the role in training camp and the team opted to trade for veteran RB Brian Robison (92-400-2) to fill that role instead. The 25-year-old Guerendo averaged 5.0 yards per carry in his rookie season, so it was a bit surprising to see San Francisco's coaching staff give him zero carries in 2025. The Louisville product was healthy for the majority of the schedule and appeared in 14 games as a member of the special teams unit. Guerendo still has two years left on his rookie contract, but it doesn't appear that the 49ers view the running back as part of the team's long-term vision on offense.

Isaac Guerendo
RB SF (14)
Sun 12/28/25 7:17 PM

Guerendo (coach's decision) is inactive for Sunday night's contest against Chicago.
EDGE Analysis
Guerendo will be a healthy scratch for the second straight week after having played in the team's previous 14 contests. Jordan James will get another nod as the 49ers' No. 3 running back behind Christian McCaffrey and Brian Robinson in Week 17.

Isaac Guerendo
RB SF (14)
Mon 12/22/25 6:57 PM

Guerendo (coach's decision) is inactive for Monday night's game against the Colts.
EDGE Analysis
Guerendo has appeared in all 14 games this season leading up to Monday night, but rookie Jordan James is getting the nod over him against the Colts as the Niners' RB3 behind Christian McCaffrey and Brian Robinson. All of Guerendo's 173 snaps this season have come on special teams.

Isaac Guerendo
RB SF (14)
Mon 12/15/25 12:52 PM

Guerendo logged three snaps on special teams in Sunday's 37-24 win over the Titans.
EDGE Analysis
Guerendo remained a non-factor on offense behind Christian McCaffrey and Brian Robinson on San Francisco's running back depth chart. The 25-year-old Guerendo once returned kickoffs for the 49ers, but the team has removed him from that role completely since Week 5. Barring a string of catastrophic injuries in the backfield, Guerendo can safely be ignored during the fantasy playoffs.

Isaac Guerendo
RB SF (14)
Wed 10/29/25 11:50 AM

Guerendo played all 10 of his snaps on special teams in Sunday's 26-15 loss to the Texans.
EDGE Analysis
As a rookie last season, Guerendo showcased some explosiveness out of the San Francisco backfield with averages of 5.0 yards per carry and 10.1 yards per reception over 16 games, but he has yet to play a snap on offense in the 49ers' first eight games of 2025. With lead back Christian McCaffrey having thus far stayed healthy while handling huge snap and touch counts each week, Brian Robinson has picked up the remaining scraps left over in the backfield. So long as McCaffrey and Robinson are able to avoid injury, Guerendo looks as though he'll be limited to a role on kickoff returns and kick-coverage units.

Isaac Guerendo
RB SF (14)
Fri 10/3/25 2:33 PM

Guerendo ran back one kickoff for 18 yards while receiving no carries or targets in Thursday's 26-23 overtime win over the Rams.
EDGE Analysis
Christian McCaffrey continued to operate as San Francisco's bell cow (88 percent) while Brian Robinson (14 percent) remained the clear No. 2, which leaves Guerendo parked in the garage when the team is on offense. The 2024 fourth-round selection is stuck on special teams for the foreseeable future, needing an injury ahead of him on the depth chart to open up playing time. Guerendo generates no fantasy value in his current role when the 49ers visit the Buccaneers in Week 6.

Isaac Guerendo
RB SF (14)
Mon 9/29/25 2:04 PM

Guerendo logged 14 snaps on special teams and was not used on offense in Sunday's 26-21 loss to the Jaguars.
EDGE Analysis
Guerendo couldn't even make an appearance in the box score as a return man after WR Skyy Moore handled all punt and kick returns Sunday. The 25-year-old Guerendo has logged zero snaps on offense through four games this season, leaving no room for fantasy utility as we encroach the quarter point of the season. Managers should have no concerns leaving Guerendo in the free-agent pool for Thursday's tilt against the Rams.

Isaac Guerendo
RB SF (14)
Mon 9/22/25 2:14 PM

Guerendo did not receive a carry while gaining 19 yards on a kickoff return in Sunday's 16-15 win over the Cardinals.
EDGE Analysis
Guerendo continued to be used exclusively on special teams, logging all 15 of his snaps there Sunday. Brian Robinson was the only running back to receive any carries outside of starter Christian McCaffrey. Guerendo carries no fantasy value heading into a Week 4 matchup against Jacksonville.

Isaac Guerendo
RB SF (14)
Mon 9/15/25 2:18 PM

Guerendo returned two kickoffs for 47 yards and was not used on offense in Sunday's 26-21 win over the Saints.
EDGE Analysis
Guerendo failed to see the field on offense Sunday, logging all 17 of his snaps on special teams. Veteran backup Brian Robinson continues to handle all of the touches starter Christian McCaffrey doesn't gobble up on game days. More of the same can be expected against the Cardinals in Week 3, leaving Guerendo off the fantasy radar until an injury opens up playing time for the sophomore.

Isaac Guerendo
RB SF (14)
Mon 9/8/25 2:59 PM

Guerendo played 15 snaps on special teams and did not receive a carry in Sunday's 17-13 win over the Seahawks.
EDGE Analysis
The good news for Guerendo was that he was fully cleared from the shoulder injury that limited him in camp. That bad news for the sophomore tailback is that new addition Brian Robinson usurped him on the depth chart. Guerendo dropped to third in the pecking order and was limited to special teams, returning one kickoff for 16 yards. In his current role, Guerendo provides no fantasy utility heading into next Sunday's tilt against the Saints.