49ers coach Kyle Shanahan said Monday that Guerendo (shoulder) is expected to miss a couple weeks, Matt Maiocco of NBC Sports Bay Area reports.

EDGE Analysis

Guerendo made an early exit from Saturday's practice and apparently won't be back for a while. It sounds like he has a chance to be ready for Week 1, but a preseason appearance probably isn't in the cards. Guerendo's absence could give rookie Jordan James more opportunities to mix in with the first-team offense, especially on days when Christian McCaffrey is rested.

Guerendo had an early departure from practice Saturday due to an apparent shoulder injury, Jennifer Lee Chan of NBC Sports Bay Area reports.

EDGE Analysis

The possible injury occurred during special-teams drills. It's not yet clear how severe the issue may be, though that should become more evident once 49ers coach Kyle Shanahan chimes in and/or based on Guerendo's practice status in the days ahead. Guerendo is the favorite to work as San Francisco's No. 2 running back this season and should also see action as a kick returner.

Guerendo (knee/ankle) was an active participant at voluntary OTAs, per the 49ers' official site.

EDGE Analysis

Guerendo sustained MCL and ankle sprains in his left leg during San Francisco's regular-season finale, but the 2024 fourth-round pick appears back to full health ahead of mandatory minicamp, which will take place June 10-11. Christian McCaffrey also looks fully healthy after having been limited to four appearances in 2024, which leaves Guerendo competing for No. 2 reps entering Year 2 of his career. The 49ers saw fit to trade Jordan Mason to Minnesota this offseason and let Elijah Mitchell link up with the Chiefs in free agency, though the team did re-sign Patrick Taylor and select Jordan James in the fifth round of the 2025 NFL Draft. Guerendo's combo of athleticism and explosiveness makes him a high-upside backup to McCaffrey, but injuries have been a consistent roadblock for him dating back to college.

Guerendo has been diagnosed with MCL and ankle sprains in his left leg following an MRI on Monday, but he didn't damage the ACL in his left knee during Sunday's loss at Arizona, Matt Barrows of The Athletic reports.

EDGE Analysis

The 49ers' 2024 campaign is over, but the team's season finale included yet another RB injury. On only his second carry of Sunday's game, Guerendo had his left leg twisted under him as he was tackled, and he needed a cart to go to the locker room. He thus is one of four San Francisco running backs to enter the offseason focusing on rehab. The others are Christian McCaffrey (knee), Jordan Mason (ankle) and Elijah Mitchell (hamstring). Guerendo, a 2024 fourth-round pick, proved to be effective when given the chance as a rookie, turning 84 carries into 420 yards (5.0 YPC) and four touchdowns and hauling in 15 of 16 targets for 152 yards in 16 appearances.

Coach Kyle Shanahan said after Sunday's 47-24 loss to the Cardinals that Guerendo (knee/ankle) likely suffered an MCL sprain and will undergo further testing Monday, Lindsey Pallares of the 49ers' official site reports.

EDGE Analysis

Guerendo suffered knee and ankle injuries, with the knee injury likely to be an MCL sprain. The results of Monday's tests should help provide clarity on the recovery timeline for Guerendo. The 49ers' season came to a close with Sunday's defeat in the regular-season finale.

Guerendo won't return to Sunday's game at Arizona due to knee and ankle injuries.

EDGE Analysis

Guerendo had his left leg twisted under him on his second carry of the game, and his teammates quickly motioned to the sideline for assistance. He eventually was carted off the field and ruled out not long after. With Guerendo unavailable, the 49ers will entrust the run game in Patrick Taylor and FB Kyle Juszczyk for the rest of their season finale.

Guerendo took nine carries for 34 yards while bringing in all four targets for 65 yards in Monday's 40-34 loss to the Lions.

EDGE Analysis

Guerendo made a successful return from a one-game layoff due to foot and hamstring injuries Week 17. The fourth-round rookie looked no worse for wear, generating 99 yards from scrimmage in a pass-heavy game plan. The only negative aspect of Guerendo's fantasy line was a lack of trips to the end zone after quarterbacks Brock Purdy (elbow) and Joshua Dobbs vultured a pair of short touchdown rushes. Guerendo may find himself more involved as a rusher if San Francisco's injured starting QB is unable to suit up against the Cardinals on Sunday.

Guerendo (foot/hamstring) doesn't have a designation for Monday's game versus the Lions, Cam Inman of The San Jose Mercury News reports.

EDGE Analysis

Guerendo managed limited practices Thursday and Friday due to foot and hamstring injuries that sidelined him last Sunday in Miami. Adam Schefter of ESPN then reported Saturday afternoon that Guerendo was expected to play Week 17, which now is a formality following comments from coach Kyle Shanahan. Guerendo thus will pace the 49ers backfield Monday after doing so Weeks 14 and 15, when he combined for 37 touches for 203 total yards and two rushing TDs.

Guerendo (foot/hamstring) is expected to play Monday against the Lions, Adam Schefter of ESPN reports.

EDGE Analysis

The 49ers have yet to post their final Week 17 injury report, but he seems destined to be listed as questionable considering he was limited in practice Thursday and Friday due to the foot and hamstring issues that sidelined him Week 16 at Miami. Assuming he's able to suit up Monday, he should take on the lead role out of San Francisco's backfield, which amounted to 37 touches for 203 yards from scrimmage and two rushing TDs between Weeks 14 and 15.

Guerendo (foot/hamstring) practiced in a limited capacity Friday, Nick Wagoner of ESPN.com reports.

EDGE Analysis

Guerendo now has managed back-to-back capped sessions to kick off Week 17 prep as he looks to put foot and hamstring injuries further in the rearview mirror. He sat out the 49ers' Week 16 loss at Miami due to the health concerns, and Saturday's practice report may provide a sense of his odds to return to action Monday against the Lions. If he's cleared for that contest, Guerendo likely will slot back in as the 49ers' lead runner over Patrick Taylor.