Guerendo (foot) was listed as a non-participant on Monday's estimated injury report, Nick Wagoner of ESPN.com reports.

EDGE Analysis

Guerendo's first career start Sunday against the Bears was fruitful until he exited in the fourth quarter due to a foot injury. Prior to his departure, he notched 128 yards from scrimmage and two rushing TDs on 17 touches. Coach Kyle Shanahan revealed the nature of the injury Monday, calling it a sprain and the running back day-to-day, per Nick Wagoner of ESPN.com. Shanahan also told Lindsey Pallares of the 49ers' official site that the team will "evaluate him over the next few days and see if he's got a shot" to play Thursday against the Rams. If Guerendo ultimately isn't able to go Week 15, he'll pass off the backfield to Patrick Taylor, while Israel Abanikanda (inactive Week 14) and practice-squad member Ke'Shawn Vaughn (two carries for four yards Sunday) will be the reserve options.

San Francisco head coach Kyle Shanahan said Monday that Guerendo has been diagnosed with a foot sprain and will be considered day-to-day heading into Thursday's game against the Rams, Nick Wagoner of ESPN.com reports.

EDGE Analysis

Shanahan said that the team will "evaluate [Guerendo] over the next few days, to see if he'll have a shot" to suit up for Thursday Night Football, per Adam Schefter of ESPN. Before exiting Sunday's 38-13 win over the Bears in the fourth quarter, Guerendo compiled 128 yards from scrimmage and two touchdowns while operating as San Francisco's lead backfield option. In the event that Guerendo isn't able to play Thursday, Patrick Taylor will be the next man up at running back, with Christian McCaffrey (knee), Jordan Mason (ankle) and Elijah Mitchell (hamstring) all on IR. The 49ers also have Ke'Shawn Vaughn and Israel Abanikanda available behind Taylor.

Coach Kyle Shanahan said after Sunday's 38-13 win over the Bears that Guerendo possibly has a foot sprain, Eric Branch of the San Francisco Chronicle reports.

EDGE Analysis

Guerendo exited in the fourth quarter due to a foot injury after compiling 128 scrimmage yards and two touchdowns. If Guerendo joins Christian McCaffrey (knee), Jordan Mason (ankle) and Elijah Mitchell (hamstring) on the sidelines Thursday against the Rams, Patrick Taylor would be the next man up in a 49ers backfield that also includes Ke'Shawn Vaughn and Israel Abanikanda. A potential return timeline for Guerendo has yet to be established.

Guerendo (foot) is questionable to return to Sunday's game against the Bears. He rushed 15 times for 78 yards and two touchdowns while catching both of his targets for 50 yards prior to the injury.

EDGE Analysis

Guerendo went to the locker room in the fourth quarter, and he's likely done for the day with the 49ers holding onto a comfortable lead. Prior to the injury, Guerendo excelled in the lead role as San Francisco worked without Christian McCaffrey (knee) and Jordan Mason (ankle), who are both on IR. Patrick Taylor will help the 49ers run out the clock. Guerendo will need to heal up quickly to be ready to face the Rams on Thursday in Week 15.

With Christian McCaffrey (knee) and Jordan Mason (ankle) in line to be placed on injured reserve, Guerendo is expected to take over as the 49ers' starting running back, Adam Schefter of ESPN reports.

EDGE Analysis

McCaffrey will miss at least the remainder of the regular season with his sprained PCL, and Mason is dealing with a high-ankle sprain. The injuries vault Guerendo to the top of the depth chart. The rookie has seen limited work as a rookie this season, but he's averaged a crisp 5.9 yards per carry on his 42 totes, turning them into 246 yards and two touchdowns. He's added five catches for 19 yards on six targets. Guerendo is a size-speed specimen at 6-foot and 221 pounds with a 4.33 40-yard dash time. He will be the top waiver-wire priority in fantasy leagues this week.

Guerendo took four carries for 19 yards and a touchdown while losing three yards on his only reception in Sunday's 35-10 loss to the Bills.

EDGE Analysis

Guerendo got some extra run in the second half after starter Christian McCaffrey (knee) left the game due to injury at halftime. Jordan Mason (13-78-0) took over as the primary rusher from there on out, but Guerendo benefited from scoring the 49ers' only offensive touchdown in the blowout loss. Mason is the name to grab on waivers this week, but he showed some durability issues handling the starter's role earlier this season in addition to being evaluated for a concussion against Buffalo. Guerendo is more of a stash option for next Sunday's tilt against the Bears, but he carries some appeal for those in deeper leagues with CMC likely done for the year.

Guerendo had one carry for zero yards in Sunday's 23-20 win over Tampa Bay.

EDGE Analysis

With star running back Christian McCaffrey (Achilles) returning to action and backup Jordan Mason (shoulder) healthy, Guerendo was relegated to third on San Francisco's depth chart. The rookie logged just three snaps on offense (five percent) while taking his only touch for no gain. Guerendo produced a pair of strong fantasy performances in the weeks covering for his injured teammates, but managers can safely move on from the Louisville product in such a reduced role.

Guerendo rushed 14 times for 85 yards and a touchdown while securing three of four targets for 17 yards in Sunday's 30-24 win over Dallas.

EDGE Analysis

Guerendo took over mid-game after Jordan Mason (shoulder) aggravated a nagging AC joint injury early in the contest. The 24-year-old Guerendo performed as he did the last time this scenario unfolded, which is one of the reasons the rookie was pegged a deep sleeper heading into drafts this year. The downside from a fantasy perspective is that San Francisco will observe its bye this upcoming week, and star running back Christian McCaffrey (Achilles) has a shot at returning in Week 10 against Tampa Bay. Guerendo still is worth looking at if he was dropped prior to Mason's activation Sunday, but be aware of CMC's status come Nov. 10.

Guerendo rushed once for two yards and caught his only target for five yards in Sunday's 28-18 loss to Kansas City.

EDGE Analysis

Guerendo was coming off of his best game as a pro last week (10-99-0), but the rookie took a back seat to Jordan Mason (shoulder) who was able to suit up after suffering a sprained AC joint against the Seahawks in Week 6. The 24-year-old Guerendo saw just two touches when the dust settled from Sunday's loss, fumbling on his lone carry despite not losing possession. With Mason handling his usual workload and Christian McCaffrey (Achilles) nearing a return, it appears that Guerendo can safely be returned to the waiver wire ahead of next Sunday's tilt against the Cowboys.

Guerendo rushed 10 times for 99 yards in the 49ers' 36-24 win over the Seahawks on Thursday night.

EDGE Analysis

The rookie saw the most robust volume of his young career in the victory, as Jordan Mason's multiple exits from the game due to a shoulder injury left Guerendo as the lead back for all but one play in the second half. Guerendo had scuffled to just 23 yards on nine carries when he took the handoff on the opening play of the 49ers' final possession, a play on which he broke off a 76-yard run up the right side of the field that he nearly scored on. The rookie fourth-round pick was caught from behind but made sure his momentum didn't carry him into the end zone as he went down, forcing the Seahawks to burn two timeouts before Kyle Juszczyk scored a game-sealing six-yard touchdown. San Francisco has 10 days before a Super Bowl rematch with the Chiefs on Sunday, Oct. 20, but if neither Mason nor Christian McCaffrey (Achilles/calf) is able to suit up for that contest, Guerendo would be in line to serve as San Francisco's No. 1 back for that marquee battle.