Coach Kyle Shanahan said Sunday he's "hopeful" Guerendo (hamstring) will be able to resume practicing this week and potentially play in Friday's preseason finale against the Raiders, Matt Barrows of The Athletic reports.

EDGE Analysis

Guerendo has missed more than three weeks of training camp, including San Francisco's first two preseason games, due to a hamstring injury sustained July 24. The rookie fourth-rounder will be in a position to receive valuable reps if he's indeed able to return this week, with all of Christian McCaffrey (calf), Elijah Mitchell (hamstring) and Jordan Mason (hip) nursing injuries of their own. Friday's exhibition matchup against the Raiders represents Guerendo's last chance to log game reps before the 49ers take on the Jets in Week 1 on Monday, Sept. 9.

Guerendo is expected to be sidelined multiple weeks due to the hamstring injury he sustained last week, Adam Schefter of ESPN reports.

EDGE Analysis

Based on Schefter's report, it seems likely that the rookie fourth-rounder will be unavailable for the 49ers' preseason opener, at a minimum. Once he's back in the mix, Guerendo will compete with Jordan Mason, Patrick Taylor and Cody Schrader for backfield slotting behind Christian McCaffrey and Elijah Mitchell.

Guerendo departed Wednesday's training camp practice early due to a hamstring injury, Jennifer Lee Chan of NBC Sports Bay Area reports.

EDGE Analysis

The severity of Guerendo's injury isn't known, with head coach Kyle Shanahan saying that the running back will need to be evaluated further, according to Lindsey Pallares of the 49ers' official site. It's a tough start for the rookie speedster, who is working to carve out a role behind Christian McCaffrey and Elijah Mitchell. Guerendo dealt with recurring soft-tissue injuries in college, so his status will warrant close monitoring.