McCaffrey was named the 2025 Comeback Player of the Year on Thursday, Matt Barrows of The Athletic reports.

EDGE Analysis

McCaffrey was limited to only four games in 2024 due to Achilles and knee injuries, but he managed to suit up for all 17 regular-season contests in 2025. He also handled an impressive 413 total touches while racking up 2,126 yards from scrimmage. McCaffrey's rushing efficiency took a concerning dip, but his involvement as a pass catcher should help him retain elite fantasy value in 2026.

McCaffrey rushed the ball 11 times for 35 yards in Saturday's 41-6 divisional-round loss to the Seahawks. He added five receptions on six targets for 39 yards.

EDGE Analysis

McCaffrey had a relatively muted stat line by his lofty standards, though he was one of the few players who was effective to any degree in the 49ers' offense. His longest gains from scrimmage all came as a receiver, as four of his five receptions went for at least eight yards. McCaffrey was limited as a rusher by the game script, and he was also forced to depart from the game on two separate occasions due to a stinger in his left shoulder. While it was a disappointing loss, McCaffrey turned in a standout effort for the campaign as a whole, logging 2,126 yards from scrimmage and 17 total touchdowns across 17 regular-season contests.

McCaffrey (shoulder) returned to Saturday's divisional-round game against the Seahawks, Eric Branch of the San Francisco Chronicle reports.

EDGE Analysis

McCaffrey missed two drives for the 49ers but was able to check back in midway through the third quarter after dealing with a stinger. He should serve as the team's lead back, though the injury may limit his reps.

McCaffrey is questionable to return to Saturday's divisional-round game against the Seahawks due to a stinger, Nick Wagoner of ESPN.com reports.

EDGE Analysis

McCaffrey suffered the injury on San Francisco's final drive of the first half, and he's remained out to start the third quarter. He was spotted having his left shoulder worked on, though he remained on the sideline with his helmet on. Brian Robinson has taken over as the lead back in McCaffrey's absence.

McCaffrey rushed 15 times for 48 yards and caught six of eight targets for 66 yards and two touchdowns in Sunday's 23-19 playoff win over the Eagles.

EDGE Analysis

TE George Kittle (Achilles) went down midway through the second quarter of Sunday's wild-card game, so the 49ers had to rely on its remaining superstar in order to overcome the Eagles' dominant defense. McCaffrey responded to the moment and generated well over 100 yards from scrimmage while catching a pair of touchdown passes -- including the game-winning score -- to advance his club to the next round. The 49ers' dual-threat running back was bottled up against the Seahawks when these two division foes met in the regular-season finale (16 touches for 57 yards), but McCaffrey should find himself busier as a receiver in the divisional round rematch with Kittle expected to miss the remainder of the postseason.

McCaffrey rushed the ball eight times for 23 yards in Saturday's 13-3 loss to the Seahawks. He added six receptions on seven targets for 34 yards.

EDGE Analysis

Seattle dominated time of possession, limiting San Francisco to only 42 offensive plays. That limited volume for all of their skill-position players, including McCaffrey. Even when he did get touches, McCaffrey was stifled by the elite Seahawks defense, with his longest gain from scrimmage going for only nine yards. Despite the disappointing close, McCaffrey concludes the regular season with an excellent 2,126 yards from scrimmage and 17 total touchdowns.

McCaffrey (back) doesn't have a designation for Saturday's game against the Seahawks, Nick Wagoner of ESPN.com reports.

EDGE Analysis

McCaffrey initially dealt with a back injury in the fourth quarter of this past Sunday's win against the Bears. Per David Lombardi of SFStandard.com, the issue was described as stiffness by the running back himself Tuesday, when he didn't practice, but McCaffrey got back on the practice field Wednesday as a limited participant and now is clear for Week 18. McCaffrey is four catches away from reaching 100 for the third time in his career.

McCaffrey (back) practiced in a limited capacity Wednesday, Matt Maiocco of NBC Sports Bay Area reports.

EDGE Analysis

McCaffrey was held out of Tuesday's session due to back stiffness, which stems from the evident back issue he was dealing with in the waning moments of this past Sunday's win against the Bears. He did most of his damage before then in the Week 17 win, racking up 181 yards from scrimmage and a rushing TD on 27 touches. Earlier Wednesday, GM John Lynch said on Cam Inman of The San Jose Mercury News that McCaffrey and other key 49ers were trending toward playing Saturday against the Seahawks, and the running back's upgrade in activity level from Tuesday backs up that claim. McCaffrey will have one more chance to get back to full before potentially being tagged with a designation for Week 18 action.

San Francisco general manager John Lynch said Wednesday that McCaffrey (back) is trending in the right direction to play Saturday against the Seahawks, Cam Inman of The San Jose Mercury News reports.

EDGE Analysis

McCaffrey could not practice Tuesday due to back stiffness, leaving him two more opportunities to retake the practice field in advance of Saturday night's showdown against Seattle, the winner of which will clinch the NFC West title and the No. 1 playoff seed in the NFC. The 49ers may in part simply be taking a cautious approach to McCaffrey's health due to both his importance as the focal engine of the team's offense and the fact that he's handled 20-plus touches in five consecutive games. McCaffrey previously played through this back injury early December, but he hadn't been listed on San Francisco's injury reports in Week 16 and Week 17.

McCaffrey (back) will not practice Tuesday, Matt Barrows of The Athletic reports.

EDGE Analysis

Per David Lombardi of SFStandard.com, McCaffrey said the back stiffness isn't anything serious. McCaffrey dealt with the back issue earlier this month but was ultimately active against the Titans back in Week 15. He hasn't been listed on the injury report since, but the Niners are coming off a back-and-forth fight with the Bears on Sunday night and have a quick turnaround for the battle for the NFC's No. 1 seed against the Seahawks on Saturday night. More will be known about CMC's availability for Week 18 as the week progresses.