Coach Sean McDermott said Friday that Rousseau (foot) is ruled out for Sunday's game against the Jaguars, Katherine Fitzgerald of The Buffalo News reports.

EDGE Analysis

Rousseau popped up with a foot injury that forced him to miss practice Wednesday, and he will need to miss at least one game as he works his way back to full health. In Rousseau's stead, A.J. Epenesa will stand to handle an expanded role on defense versus Jacksonville.

Rousseau (foot) did not participate at practice Wednesday, Chris Brown of the Bills' official site reports.

EDGE Analysis

It's not clear whether he picked up the injury during the week or during Sunday's game versus the Dolphins. It's also not clear whether his status for Week 5 is actually in any jeopardy, so it will be worth keeping an eye on Buffalo's injury reports Thursday and Friday.

Rousseau had three tackles including two sacks in Sunday's 48-20 win over the Dolphins.

EDGE Analysis

Rousseau is up to 3.0 sacks on the season, tied for second on the team with Ed Oliver and half a sack behind Leonard Floyd. The defensive front should soon receive even more support with Von Miller (knee) returning to practice this week.

Rousseau finished the 2022 regular season with 37 tackles, eight sacks, four passes defended and one forced fumble over 13 games.

EDGE Analysis

The 8.0 sacks -- which co-led the team with Von Miller -- is the number that sticks out the most considering Rousseau missed time with an ankle injury and also that the Bills typically rotate their defensive linemen more than most teams. He also stepped it up after Miller was lost for the season with a knee injury. Rousseau has mammoth size and has now proven a knack for getting after the quarterback, so he could be relied upon for more in the 2023 season, as the Bills have some cap issues and likely won't be able to run as deep as they have the last two seasons.

Rousseau (ankle) was a full participant in practice Monday.

EDGE Analysis

Rousseau said Sunday that he feels close to full health, and Monday's full participation backs up that notion. After missing Buffalo's previous three games, Rousseau's poised to return for Thursday's road game in New England.

Rousseau, who has missed the last three games with an ankle injury, returned to practice Sunday, Alec White and Maddy Glab of the Bills' official site report. Said Rousseau, "I'm feeling good man, pretty close for sure."

EDGE Analysis

Rousseau has posted 5.0 sacks through just eight games, and with Von Miller being out at least a week or two with a knee injury, the second-year pass rusher's presence would be highly welcomed as the Bills make a push for a division crown in what's been a highly competitive AFC East all season. The Bills play their next three games against division foes, beginning with Thursday's game against the rival Patriots.

Rousseau (ankle) has been ruled for Thursday's contest versus the Lions, Alaina Getzenberg of ESPN.com reports.

EDGE Analysis

Rousseau will be unavailable for a third consecutive game as he continues to nurse an ankle injury as Buffalo faces off with Detroit on Thanksgiving Day. He'll now shift his focus to a potential return in Week 13 against the Patriots.

Rousseau (ankle) has been ruled out for Sunday's contest against the Browns, Alaina Getzenberg of ESPN.com reports.

EDGE Analysis

Rousseau will miss a second consecutive game in Week 11 after suffering a high-ankle sprain in Week 9 versus the Jets. The defensive end will now shift his focus to being ready for the Bills' Thanksgiving Day matchup with the Lions on Thursday.

Rousseau missed practice Wednesday due to an ankle injury.

EDGE Analysis

The second-year defensive end has a high-ankle sprain and it may be a bit of a surprise if he's able to return this week against the Browns. Even Week 12 may be a tough task with the Bills set to play Thanksgiving Day.

Rousseau (ankle) has been ruled out for Sunday's game against the Vikings, Maddy Glab of the Bills' official site reports.

EDGE Analysis

Rousseau suffered a high-ankle sprain in a Week 9 matchup with the Jets, missing the second half of that contest. The 22-year-old defensive end has recorded 21 total tackles so far this season, and his five sacks are good for the second-highest total on Buffalo's formidable defense. In Rousseau's absence, A.J. Epenesa and Shaq Lawson should see increased playing time.