Aiyuk (hamstring) is listed as inactive Sunday versus the Cardinals, Nick Wagoner of ESPN.com reports.

EDGE Analysis

Aiyuk will be sidelined for his first potential NFL action due to a mild hamstring strain that has plagued him since Aug. 23 and held him to a DNP/LP/LP practice regimen in advance of the season opener. With Aiyuk out and Deebo Samuel (foot) on injured reserve, the 49ers will be shorthanded at wide receiver. Kendrick Bourne, Trent Taylor, Dante Pettis and Richie James will be the options available to Jimmy Garoppolo.

Aiyuk (hamstring) remained limited Friday at practice and is listed as questionable for Sunday's game against the Cardinals, Darren Urban of the Cardinals' official site reports.

EDGE Analysis

Aiyuk closes out the week with back-to-back limited sessions after being held out entirely Wednesday. Matt Maiocco of NBC Sports Bay Area believes the rookie could have a limited role even if he's active for the season opener, with the hamstring injury and corresponding missed practice time potentially restricting his involvement in the offense. There's also some concern that poor air quality in Santa Clara could force the NFL to relocate or postpone the game, so it's a messy situation all around. With Deebo Samuel (foot) already ruled out, the team has Kendrick Bourne, Trent Taylor, Dante Pettis and Richie James as its healthy options at wide receiver.

Aiyuk (hamstring) was limited in practice Thursday, Nick Wagoner of ESPN.com reports.

EDGE Analysis

Aiyuk took the first step toward being available Week 1 after dealing with a mild left hamstring strain during the later stages of training camp. He seems to have a far better chance of suiting up Week 1 versus the Cardinals that Deebo Samuel (foot), who has yet to practice this week. Friday's injury report could clear up the situation once and for all, but in the end the 49ers' aren't required to make a final decision on Samuel or Aiyuk until 90 minutes before Sunday's 4:25 p.m. ET kickoff.

Aiyuk (hamstring) didn't practice Wednesday, David Lombardi of The Athletic reports.

EDGE Analysis

Coach Kyle Shanahan expected as much as Aiyuk looks to put a mild left hamstring strain behind him. The rookie first-round pick has two more opportunities to prove his health before Sunday's contest against the Cardinals, but the 49ers' receiving corps could be less than expected if one or both of Aiyuk and Deebo Samuel (foot) sit out this weekend.

San Francisco head coach Kyle Shanahan said that he doesn't expect Aiyuk (hamstring) to practice Wednesday, David Lombardi of The Athletic reports.

EDGE Analysis

The 49ers' first official injury report of the season will be released later Wednesday, revealing whether or not Aiyuk was actually able to put any work in. Even if he's listed as a non-participant Wednesday as expected, the rookie first-round pick would still have a shot at playing in Sunday's season opener against the Cardinals with limited activity in session Thursday or Friday.

Aiyuk (hamstring) did not participate in Monday's team practice, Nick Wagoner of ESPN.com reports.

EDGE Analysis

Head coach Kyle Shanahan stated that he still hoped Aiyuk would return to practice soon after suffering a mild hamstring strain Aug. 23, but the rookie wideout remains sidelined on the first day of organized team activities this week. The team didn't offer much of a concrete update on either Aiyuk or fellow playmaker Deebo Samuel (foot), but expect to see a clearer picture of what the 49ers' starting wideout corps will look like as we progress later in the practice week. Kendrick Bourne, Dante Pettis and Trent Taylor could all see boosts in snaps if either or both of the talented young receivers is unable to suit up Sunday against Arizona.

Head coach Kyle Shanahan said that he is hopeful Aiyuk (hamstring) can return to practice next week, Jennifer Lee Chan of NBC Sports Bay Area reports.

EDGE Analysis

Aiyuk suffered a mild hamstring strain during practice Aug. 23, and his status for Week 1 is currently up in the air. If the rookie is indeed able to return to practice next week, it would bode well for his availability for the season opener against the Cardinals on Sept. 13. Aiyuk may be thrust into a starting role if fellow injured wideout Deebo Samuel (foot) is unable to suit up to begin the year. Either way, the 22-year-old put himself in position to have a role in Kyle Shanahan's offense once he is ready to return after an impressive training camp.

Coach Kyle Shanahan called Aiyuk "week-to-week" due to a mild left hamstring strain, Nick Wagoner of ESPN.com reports.

EDGE Analysis

Prior to suffering the injury at Sunday's practice, Aiyuk was thoroughly impressing in camp. He may have been helped by the absence of Deebo Samuel (foot) and others in the receiving corps, but the rookie first-round pick's performance on the field was helping to put himself on the fantasy radar. Now, Aiyuk will focus on his recovery with the aim of getting healthy by the 49ers' regular-season opener Sept. 13 versus the Cardinals.

Aiyuk (hamstring) was unable to finish practice Sunday after he "appeared to come up lame after a deep route," per Jennifer Lee Chan of NBC Sports Bay Area.

EDGE Analysis

Nick Wagoner of ESPN.com adds that Aiyuk, who "was in the midst of another strong practice," appeared to tweak his hamstring on the play. As long as the wideout's injury doesn't linger, the 25th overall pick in the 2020 draft figures to see a key role in the 49ers' passing attack from the get-go, with projected starter Deebo Samuel still recovering from a foot injury.

Aiyuk is a candidate to fill in for injured starter, Deebo Samuel (foot), to begin the regular season, Josh Schrock of NBC Sports Bay Area reports.

EDGE Analysis

Samuel was lined up to serve as the 49ers' top wide receiver following his stellar 2019 rookie campaign, but an offseason foot injury put his status for Week 1 in jeopardy. With GM John Lynch stating that his top wideout could miss multiple games to begin the season, Aiyuk could be in line to replace his production out of the gates. The first-round pick out of Arizona State was high on coach Kyle Shanahan's draft board in this year's receiver-heavy draft, even drawing comparison to Hall of Fame wideout, Isaac Bruce, from his new head coach. Aiyuk was originally expected to compete for snaps behind Samuel and veteran Kendrick Bourne, but this new development could thrust the rookie into a prominent role from the get go. Just as we saw with Samuel in 2019, if Aiyuk is able to impress early on, the versatile wideout could grab a hold of a starting job and force his way into the starting lineup for the remainder of the year.