PUPBrandon Aiyuk
WR SF (14)
Mon 11/10/25 5:57 PM

Coach Kyle Shanahan said Monday that the 49ers don't intend to open Aiyuk's (knee) practice window this week, Nick Wagoner of ESPN.com reports.
EDGE Analysis
Aiyuk remains in the rehab stages of the torn ACL and MCL that he suffered in his right knee Week 7 of last season. Shanahan did tell David Lombardi of SFStandard.com last Wednesday that he's "pretty confident" Aiyuk will play at some point this season, but it's unlikely to happen this coming Sunday and likely for at least a few more weeks after that point.

PUPBrandon Aiyuk
WR SF (14)
Wed 11/5/25 4:19 PM

San Francisco head coach Kyle Shanahan said Wednesday that he's "pretty confident" Aiyuk (knee) will play at some point this season, David Lombardi of SFStandard.com reports.
EDGE Analysis
That's probably not what fantasy managers want to hear, though it was already made clear Monday that Aiyuk isn't exactly close to a return. He's still on injured reserve with no designation to return to practice this week, and then he's presumably looking at a multi-week ramp-up whenever he does begin practicing. A game appearance before December would be surprising.

PUPBrandon Aiyuk
WR SF (14)
Mon 11/3/25 5:01 PM

San Francisco head coach Kyle Shanahan said that Aiyuk (knee) won't have his 21-day practice window opened this week, David Lombardi of SFStandard.com reports.
EDGE Analysis
The 49ers are continuing to evaluate Aiyuk on a week-to-week basis as he moves through the rehab process for the right knee surgery he required after suffering ACL and MCL tears in an Oct. 20, 2024 game. While the 49ers are seemingly still hopeful that Aiyuk will contribute at some point this season, a more definitive target date for his 2025 debut won't become clear until he starts practicing.

PUPBrandon Aiyuk
WR SF (14)
Mon 10/27/25 6:42 PM

Coach Kyle Shanahan said Monday that the 49ers don't intend to designate Aiyuk (knee) to return from the reserve/PUP list Wednesday, Matt Barrows of The Athletic reports.
EDGE Analysis
On Friday, Shanahan told David Lombardi of SFStandard.com that Aiyuk's 21-day practice window may open this week, but even if it doesn't, the 49ers currently are in "week-to-week mode" with the wide receiver. Aiyuk is little more than one year removed from suffering ACL and MCL tears in his right knee Week 7 of the 2024 campaign, so he still may endure a significant ramp-up process even when he's cleared to practice.

PUPBrandon Aiyuk
WR SF (14)
Fri 10/24/25 5:17 PM

Coach Kyle Shanahan said Friday that the 49ers may designate Aiyuk (knee) to return from the reserve/PUP list next week, David Lombardi of SFStandard.com reports.
EDGE Analysis
Aiyuk is a shade more than one year removed from tearing the ACL and MCL in his right knee Week 7 of last season. Once the 49ers make the aforementioned transaction, be it next week or beyond that point, the team will have a 21-day window in which to evaluate Aiyuk in practice to determine his return to action. Shanahan added that San Francisco currently is in "week-to-week mode" with Aiyuk, meaning he may need a few weeks to get up to speed before gaining clearance to play.

PUPBrandon Aiyuk
WR SF (14)
Thu 10/23/25 4:15 PM

San Francisco general manager John Lynch said Thursday that he has both hope and "evidence" that Aiyuk (knee) will soon be ready to make his 2025 debut, David Lombardi of SFStandard.com reports.
EDGE Analysis
Though Lynch didn't go into specifics regarding where exactly Aiyuk stands in his recovery from the torn ACL and MCL he sustained last October, the GM's comments indicate that the receiver has reached some necessary checkpoints in the rehab process for his surgically-repaired right knee. That being said, until the 49ers clear Aiyuk to practice and open up his 21-day evaluation window, it will be difficult to pinpoint a target date for the 27-year-old to potentially return from the PUP list. Whenever he's activated, Aiyuk could have his snap counts monitored carefully for at least a few games.

PUPBrandon Aiyuk
WR SF (14)
Mon 10/13/25 6:30 PM

Coach Kyle Shanahan said Monday that Aiyuk (knee) is getting "closer and closer" to being able to practice, but the 49ers don't have a specific timeline for the wide receiver to do so, Nick Wagoner of ESPN.com reports.
EDGE Analysis
Aiyuk remains in recovery mode from the ACL and MCL tears that he suffered in his right knee Week 7 of last season, instead residing on the reserve/PUP list to this point in the campaign. Per David Lombardi of SFStandard.com, Shanahan added, "I always look around Week 10, but I'm not putting an exact date on it." As of Week 6, Aiyuk's only notable on-field work occurred in mid-September, when he was seen running while fellow 49ers wide receivers worked in individual drills, per Wagoner.

PUPBrandon Aiyuk
WR SF (14)
Thu 9/25/25 12:30 PM

49ers GM John Lynch said Thursday that Aiyuk (knee, PUP) is "not close" to returning, David Lombardi of SFStandard.com reports.
EDGE Analysis
Lombardi believes a Week 6 return is not realistic for Aiyuk, as the wide receiver is still working to hit various markers in his recovery. Coach Kyle Shanahan said back in August that Week 6 was a reasonable target for Aiyuk's return to game action, but that is looking increasingly unlikely at this point. The 49ers will continue to work through injuries at the position, but Ricky Pearsall (knee) and Jauan Jennings (ankle) appear poised to lead this wideout room for the foreseeable future.

PUPBrandon Aiyuk
WR SF (14)
Wed 9/17/25 6:06 PM

Aiyuk (knee) did some running while his teammates were practicing Wednesday, Nick Wagoner of ESPN.com reports.
EDGE Analysis
Aiyuk remains on the PUP list, out through at least Week 4 and unable to practice with his teammates. Neither player nor team has said much about the situation of late, but coach Kyle Shanahan did suggest in mid-August that Week 6 (against Tampa Bay) was a reasonable target for Aiyuk's 2025 debut.

PUPBrandon Aiyuk
WR SF (14)
Tue 8/26/25 4:41 PM

The 49ers moved Aiyuk (knee) to the reserve/PUP list Tuesday.
EDGE Analysis
This is merely a procedural move, as coach Kyle Shanahan has circled (in his mind) a Week 6 road matchup with the Buccaneers as a possible date for Aiyuk to make his 2025 debut, per Vic Tafur of The Athletic. With this move from active/PUP to reserve/PUP, though, Aiyuk technically can return to action as early as Thursday, Oct. 2 at the Rams. He remains in recovery mode from the ACL and MCL tears that he sustained in his right knee Week 7 of last season. With Demarcus Robinson suspended for the first three games of the season, Jauan Jennings (calf) and Ricky Pearsall are the top wide receivers on San Francisco's active roster.