Aiyuk (knee) did some running while his teammates were practicing Wednesday, Nick Wagoner of ESPN.com reports.

EDGE Analysis

Aiyuk remains on the PUP list, out through at least Week 4 and unable to practice with his teammates. Neither player nor team has said much about the situation of late, but coach Kyle Shanahan did suggest in mid-August that Week 6 (against Tampa Bay) was a reasonable target for Aiyuk's 2025 debut.

The 49ers moved Aiyuk (knee) to the reserve/PUP list Tuesday.

EDGE Analysis

This is merely a procedural move, as coach Kyle Shanahan has circled (in his mind) a Week 6 road matchup with the Buccaneers as a possible date for Aiyuk to make his 2025 debut, per Vic Tafur of The Athletic. With this move from active/PUP to reserve/PUP, though, Aiyuk technically can return to action as early as Thursday, Oct. 2 at the Rams. He remains in recovery mode from the ACL and MCL tears that he sustained in his right knee Week 7 of last season. With Demarcus Robinson suspended for the first three games of the season, Jauan Jennings (calf) and Ricky Pearsall are the top wide receivers on San Francisco's active roster.

San Francisco head coach Kyle Shanahan said Monday that Week 6 could be a realistic target for Aiyuk (ACL) to take the field, Vic Tafur of The Athletic reports.

EDGE Analysis

Shanahan preempted the estimate by saying he hadn't given the date much thought, but Week 6 nonetheless seems like a fairly realistic target for Aiyuk, who is recovering from right knee surgery that he underwent last November to address ACL and MCL tears, to make his 2025 debut. In that scenario, Aiyuk would figure to begin the season on the reserve/PUP list, then begin ramping his activity level up before hopefully taking the field Sunday, Oct. 12 on the road against Tampa Bay. Even then, it's conceivable Aiyuk could get off to a slow start and ramp his way up to a full starting share of snaps, meaning it would incentivize fantasy managers to plan ahead and roster alternative options at WR. With Jauan Jennings (calf) and Jacob Cowing (hamstring) still not practicing, and Jordan Watkins (ankle) out about a month, Ricky Pearsall and Demarcus Robinson currently are operating as the 49ers' clear top two wide receivers.

San Francisco GM John Lynch said Thursday he "doesn't think" Aiyuk (ACL), who remains on the active/PUP list, will be cleared to play Week 1, Cam Inman of The San Jose Mercury News reports.

EDGE Analysis

Lynch reiterated that there's still no official timetable set for Aiyuk's recovery from right ACL and MCL tears suffered last October, but it's no surprise to hear a lack of optimism regarding his Week 1 availability. Aiyuk has yet to practice in any capacity since undergoing right knee surgery mid-November of 2024, though the 49ers have expressed optimism in his rehab progress and he's remained active in meetings and as an 'unofficial coach' on the sidelines for teammates. Realistic expectations for Aiyuk should probably involve a slow start early in the 2025 regular season, with TE George Kittle, RB Christian McCaffrey, and wide receivers Jauan Jennings (calf) and Ricky Pearsall opening the year as QB Brock Purdy's top playmakers.

San Francisco offensive coordinator Klay Kubiak said Tuesday that Aiyuk (knee), who remains on the active/PUP list, has been "kind of a coach on the side" throughout the early stages of training camp, Nick Wagoner of ESPN reports.

EDGE Analysis

Kubiak said "it's been awesome" having Aiyuk mentor his positional mates during individual drills and walkthroughs, rather than being "just isolated doing his rehab." A timetable for Aiyuk's return remains undisclosed, but although the 27-year-old wideout has reportedly thrived in his rehab activities, it would likely be unreasonable to expect him to be available Week 1 as he works his way back from right ACL and MCL tears suffered last October. Still, Aiyuk's active mental involvement lends credence to hopes that he'll be able to hit the ground running this season whenever he is cleared to play. Meanwhile, Ricky Pearsall overcame his hamstring injury and was activated from the PUP list Sunday, while Jauan Jennings (calf) is currently sidelined and has been vocal about his desire for a new contract.

Aiyuk (knee) was placed on the active/PUP list by the 49ers on Friday.

EDGE Analysis

Aiyuk is eligible to practice while on the active/PUP list, though he isn't expected to be available for training camp as he recovers from a torn ACL and MCL in his right knee sustained in October. Fellow wide receiver Ricky Pearsall (hamstring) was also placed on the active/PUP list Friday, though he's expected to have a much more optimistic recovery timeline than Aiyuk. With Jauan Jennings (calf) unhappy with his contract, there will be more opportunities for Demarcus Robinson, Jacob Cowing and Jordan Watkins during training camp.

San Francisco general manager John Lynch said Thursday that Aiyuk (knee) has been "doing a tremendous job coming back," Kevin Patra of NFL.com reports.

EDGE Analysis

Aiyuk isn't expected to be ready to participate in training camp in late July as he continues to work his way back from from a torn ACL and MCL in his right knee, but the wideout has made a positive impression with his recovery. Lynch commented that Aiyuk has been "putting in the work" and stated that "it's kind of incredible how well he's healing." It's not year clear when Aiyuk will be ready for game action, and he probably won't be active when the 49ers open the 2025 season Sept. 7 against Seattle. However, he's on track to lead the team's wideout corps when he does return following the offseason departure of Deebo Samuel to Washington.

Aiyuk (knee) is present at San Francisco's mandatory minicamp but is not practicing, though he contributed Tuesday by coaching up the team's younger receivers, Matt Barrows of The Athletic reports.

EDGE Analysis

Aiyuk's recovery remains on track, but given the severity of the injury he's working back from, he's not considered a candidate to be ready for the start of training camp in late July. The 49ers haven't yet offered a tangible timetable for Aiyuk's expected return, but he's remaining involved at team activities despite not being ready to handle on-field work. While it's still possible Aiyuk is ready for the start of the regular season after tearing the ACL and MCL in his right knee last October, it's not a guarantee he'll be back to 100 percent form at any point in 2025. Even considering his deflated ADP in 2025 fantasy drafts, Aiyuk has to be considered a high-risk, high-upside selection. As he heads into the second season of the four-year, $120 million extension he inked with the 49ers last offseason, though, Aiyuk remains positioned to lead San Francisco's wide receiver corps when fully healthy.

GM John Lynch relayed Monday that Aiyuk, who tore the ACL and MCL in his right knee in October, met with Dr. Neal ElAttrache last week and got "good reviews" in terms of the progress he's made in his recovery, Nick Wagoner of ESPN.com reports.

EDGE Analysis

That said, there is still no concrete timetable for Aiyuk's return to action. Either way, Lynch noted that despite recent trade speculation, he expects the 2020 first-rounder -- who the 49ers signed to a four-year, $120 million extension last August -- to remain with the team this coming season. Due a $22.85 million bonus Tuesday, Aiyuk recorded 25 catches (on 47 targets) for 374 yards in seven games prior to his injury, and, once he's fully healthy, he'll be in line to headline a San Francisco WR corps that no longer includes Deebo Samuel. For now, the top available options behind Aiyuk are Jauan Jennings, Ricky Pearsall and Demarcus Robinson.

Aiyuk had surgery to repair the ACL and other damage in is right knee earlier this week, David Lombardi of The San Francisco Standard reports.

EDGE Analysis

Aiyuk sustained at least ACL and MCL tears in that knee during a Week 7 loss to the Chiefs, so Lombardi's report indicates other areas may have been impacted in the hit that he took just before halftime in that game. Medical science has reached such a point that Aiyuk could make enough progress in his recovery to be ready for Week 1 of the 2025 season, but additional damage to his right knee on top of what is known may delay his next game action. With Aiyuk out for the season, Deebo Samuel, Jauan Jennings and Ricky Pearsall will be the primary wide receivers for QB Brock Purdy the rest of the way.