Mayer is out of the lineup for Wednesday's game against the Astros.

EDGE Analysis

After a string of four straight starts, Mayer will get a breather Wednesday while the Red Sox conclude their series in Houston with a day game after a night game. Isiah Kiner-Falefa will fill in for Mayer at second base.

Mayer entered Thursday's game as a pinch hitter and went 2-for-2 with a double and a run scored in a 3-0 win over Cincinnati. He finished the game at second base.

EDGE Analysis

Mayer was held out of the starting lineup against a lefty but got his chance after the Reds' Andrew Abbott was removed. Pinch-hitting for Isiah Kiner-Falefa, Mayer led off the seventh inning with a double and scored the game's first run. He later led off the ninth with a single that triggered a two-run frame. Red Sox manager Alex Cora plans a three-player platoon at second base with Mayer against righties, while Kiner-Falefa and Andruw Monasterio handle southpaws. Mayer should get his first start Saturday against Reds' right-hander Brady Singer.

Mayer is out of the lineup for Thursday's Opening Day matchup with the Reds, Tim Healey of The Boston Globe reports.

EDGE Analysis

Manager Alex Cora indicated earlier this week that Mayer would begin the season in a platoon at second base, so it's no surprise he's on the bench in favor of Isiah Kiner-Falefa with lefty Andrew Abbott on the mound for Cincinnati. Mayer had a .674 OPS over 44 regular-season games in his first taste of the majors last year and batted just .154 versus southpaws.

Red Sox manager Alex Cora said Tuesday that Mayer will be part of a platoon at second base early in the regular season, Chris Cotillo of MassLive.com reports.

EDGE Analysis

Cora indicated that Mayer will sit against left-handers with either Isiah Kiner-Falefa or Andruw Monasterio sliding in at second base against righties. Back in February, before spring training started, Cora envisioned Mayer playing against all starters, but it appears that won't be the case to start the season. Mayer was just 4-for-26 (.154) in the majors and had a .630 OPS in the minors against southpaws last year.

Manager Alex Cora said Saturday that Mayer will begin the season as the Red Sox's primary second baseman, Chris Cotillo of MassLive.com reports.

EDGE Analysis

Cora's announcement comes shortly after he named Caleb Durbin as the team's starter at third base and the Red Sox's decision to option Nick Sogard to Triple-A Worcester. Mayer has posted just a .710 OPS this spring across 44 plate appearances, but the organization feels he has done enough to win the battle at the keystone. Isiah Kiner-Falefa and Andruw Monasterio remain in camp as bench pieces.

Mayer is expected to open the regular season as the primary second baseman, Chris Cotillo of MassLive.com reports.

EDGE Analysis

While Boston manager Alex Cora hasn't said Mayer will be part of the Opening Day roster, all signs point to that being the case. On Thursday, the manager named Caleb Durbin the starter at third base, and the club optioned Nick Sogard to Triple-A Worcester, which clears a path to second base for Mayer. All that's left is for Cora, who has lauded Mayer's play during Grapefruit League games, to tell the player face-to-face before announcing it to the public.

Mayer (knee) is scheduled to play in a Triple-A game on the back fields of Red Sox camp Monday, Ian Browne of MLB.com reports.

EDGE Analysis

Mayer was scratched from the lineup ahead of Sunday's 7-2 win over the Twins due to a sore left knee, but manager Alex Cora downplayed the injury afterward, noting that the 23-year-old was scheduled to return to action Tuesday versus Atlanta. While that still could come to pass, Mayer is evidently feeling even better than the Red Sox anticipated a day later, resulting in him being cleared to play in the minor-league contest. Mayer has enjoyed a solid spring thus far with an .816 OPS in 27 plate appearances, so assuming he can avoid any further health-related setbacks this week, he should be in good position to open the season as the Red Sox's primary second baseman.

Mayer (knee) is expected to rejoin Boston's Grapefruit League lineup Tuesday against Atlanta, Jen McCaffrey of The Athletic reports.

EDGE Analysis

The 22-year-old was scratched from Sunday's spring lineup due to left knee soreness and will rest again Monday, but the injury doesn't appear to be a serious concern. After posting a .674 OPS in 44 regular-season games as a rookie last season, Mayer's .816 OPS through 27 plate appearances in spring training put him in strong position to win the starting job at second base to begin 2026.

Mayer was scratched from the lineup for Sunday's Grapefruit League game against the Twins due to left knee soreness, Christopher Smith of MassLive.com reports.

EDGE Analysis

The Red Sox haven't provided further details regarding the severity of the issue, but Mayer will presumably need at least a couple days off to recover from the injury. He's enjoyed a strong spring with an .816 OPS and 5:6 BB:K in 27 plate appearances, which appears to have given him the inside track for the Red Sox's everyday second base job.

Mayer started at second base and went 2-for-2 with two walks, an RBI and a run scored in Friday's spring game against Tampa Bay.

EDGE Analysis

Mayer followed up one of his worst games of the Grapefruit League on Thursday (0-for-4, two strikeouts) with his best Friday. Red Sox manager Alex Cora has made it clear that Mayer is not guaranteed a spot on the 26-man roster yet, but the expectation is that he'll open the season with Boston on March 26 in Cincinnati, per Christopher Smith of MassLive.com. If Mayer is on the Opening Day roster, then he'll likely be the primary starter at second base.