Juszczyk (knee) began running again Wednesday and said he may be able to return in "another week or two," Nick Wagoner of ESPN.com reports.

EDGE Analysis

Juszcyk was given a 4-to-6 week timeline after suffering the MCL sprain Oct. 7, so a return in two weeks would put him directly on track with that timeline. The 28-year-old has yet to resume practicing and is unlikely to return prior to the Nov. 11 game against the Seahawks, since the 49ers play on Thursday next week.

The 49ers announced Tuesday that Juszczyk (knee) will likely be sidelined for 4-to-6 weeks, Jennifer Lee Chan of NBC Sports Bay Area reports.

EDGE Analysis

After exiting Monday's 31-3 win over the Browns, Juszczyk was sent in for an MRI on Tuesday that confirmed the versatile fullback had sprained the MCL in his left knee. The loss of the 28-year-old for at least the next four games will deprive Jimmy Garoppolo of one of his favorite dump-off targets, while also leaving a potent San Francisco ground attack without a lead blocker. The 49ers could sign another fullback to compensate for Juszczyk's absence or have backup tight end Levine Toilolo -- a blocking specialist -- line up out of the backfield more frequently.

Juszczyk (knee) is believed to have suffered a sprained left MCL in Monday's 31-3 win over the Browns, Tom Pelissero of NFL Network reports.

EDGE Analysis

The 49ers will send Juszczyk in for an MRI later Tuesday before offering further clarity on his injury, but if the initial diagnosis proves accurate, he'll have a tough time making it back for the team's Week 6 matchup with the Rams. Juszczyk has only tallied 82 total yards on seven touches through four games, but his skills as a lead blocker have helped spark the 49ers' productive ground game this season.

Juszczyk appears to have suffered a left knee sprain, but the severity is still unknown, according to head coach Kyle Shanahan, Nick Wagoner of ESPN reports.

EDGE Analysis

Juszczyk will undergo an MRI on Tuesday, which will bring more clarity to the situation, but there's a good chance the Pro Bowl fullback could be sidelined for at least one contest. Look for more details to emerge when the team releases their practice report later this week.

Juszczyk has been carted to the locker room and is questionable to return, Matt Barrows of The Athletic reports.

EDGE Analysis

Juszczyk was able to walk off the field with some assistance from the training staff but then was spotted on a cart heading to the locker room shortly after. A fundamental piece to the 49ers' run game, the Pro Bowler is the only fullback on the roster. Should he miss an extended period of time, there's a good chance the 49ers hit the free agent market in search of a replacement.

Juszczyk caught all three of his targets for 51 yards in Sunday's 24-20 win over the Steelers.

EDGE Analysis

Juszczyk received his first notable offensive action of the season, making a game-high 27-yard reception on a wheel route out of the backfield. The versatile fullback has reached the 30-catch and 300-yard receiving plateau for each of his last two seasons with San Francisco, so the occasional big showing in a box score should be expected. Juice is rarely used as a runner, and simply doesn't get enough consistent looks to be relied upon as a fullback in the fantasy world.

Juszczyk caught one of two targets for five yards and added a six-yard run during Sunday's 41-17 win over the Bengals.

EDGE Analysis

The plays were Juszczyk's first touches of the season. Head coach Kyle Shanahan likes to use his fullback more than most coaches, and despite playing a low-priority position, Juszczyk has still managed to top 300 total yards three out of the past four seasons to go along with six total touchdowns. That's probably not enough to depend on on any given week, but don't be surprised if Juszczyk has some decent fantasy outings this season. Next up Sunday is a struggling Pittsburgh team looking to avoid a 0-3 start.

Juszczyk's X-ray on his injured hand came back negative Sunday, Matt Maiocco of NBC Sports Bay Area reports.

EDGE Analysis

Juszczyk suffered the hand injury during Saturday's win against the Chiefs but appears to be fine. Heading into the final preseason game, it's likely that the team won't risk further injury and hold the veteran out. Considering all tests checked out on his hand, Juszczyk shouldn't have a problem taking on his typical hefty role in the 49ers offense come Week 1.

The 49ers exercised Juszczyk's contract option for 2019, Adam Caplan of SiriusXM Radio reports.

EDGE Analysis

Juszczyk will receive $4.2 million for the 2019 season after catching 30 passes for 324 yards and one touchdown last season. The 27-year-old also rushed eight times for 30 yards, with mostly of his involvement in the run game coming as a blocker.

Juszczyk ran the ball twice for nine yards and caught one of two targets for 15 yards in Sunday's 48-32 loss to the Rams.

EDGE Analysis

Juszczyk did lose a fumble trying to extend the ball for a first down, but that blemish probably didn't affect anyone in fantasy unless they play in fullback leagues. All jokes aside, the 27-year-old was actually pushing very deep-league value early in the year for his receiving contributions (17 receptions, 227 yards and a touchdown through first five games). That came to a screeching halt when the 49ers' opted to use Juice's blocking skills to help protect their young, inexperienced backups as opposed to sending him out on receiving routes. Despite the offensive drought at the end of the season, Juszczyk will still finish ahead of all fullbacks for the second straight year with 30 receptions and 324 receiving yards.