Poyer (hamstring) will not play in Saturday's divisional round matchup against the Broncos, Katherine Fitzgerald of The Buffalo News reports.

EDGE Analysis

Poyer suffered a hamstring injury during the Bills' wild-card matchup against the Jaguars and will miss the second round of the playoffs. The 34-year-old is considered week to week and could be available to return in the AFC Championship Game should Buffalo beat the No.1 seed Broncos. Without the 10th-year veteran, Jordan Hancock will likely get the start at safety. Poyer has 70 tackles (31 solo), including 0.5 sacks, and three pass breakups, including one interception.

Poyer (hamstring) has been ruled out for the remainder of Sunday's wild-card game versus the Jaguars.

EDGE Analysis

Poyer has been a stalwart during his lengthy time spent in Buffalo, and he tallied 70 tackles and three passes defended over 10 regular-season appearances in 2025. If the Bills advance, it will be worth monitoring Poyer's availability for what will be a tough road challenge vs. the Broncos or Patriots.

Poyer is questionable to return to Sunday's wild-card matchup versus the Jaguars with a hamstring injury.

EDGE Analysis

Poyer recorded two tackles before exiting during the first half. The 34-year-old missed the final two games of the regular season with a hamstring issue, but he was not listed with an injury designation ahead of Sunday's wild-card game. With Poyer out for the time being, Cam Lewis and/or Sam Franklin will likely see increased playing time.

Poyer (hamstring) doesn't have an injury designation for Sunday's wild-card game against the Jaguars.

EDGE Analysis

Poyer upgraded to full practice participation Friday after being listed as limited Wednesday and Thursday. He's ready to return for his first game action since Week 16. The starting strong safety produced 70 tackles (31 solo) and had one interception among his three passes defensed across 10 regular-season appearances.

Poyer (hamstring) says that he feels ready to suit up for Sunday's game against the Jaguars, Joe Buscaglia of The Athletic reports.

EDGE Analysis

Poyer was a limited participant in Wednesday's practice, so his optimistic words and feelings seem to be reflected in his on-field performances. A reunion with Cole Bishop in the secondary would re-ignite a safety tandem that helped turn the Bills into one of the most dominant pass defenses in the latter half of the 2025 season.

Poyer (hamstring) will be listed as a limited participant on Wednesday's practice report, Maddy Glab of the Bills' official site reports.

EDGE Analysis

Poyer closed out the regular season with back-to-back absences due to a hamstring injury, but Buffalo will hope to have the starting safety back in action for Sunday's wild-card round matchup on the road against Jacksonville. Cam Lewis will figure to handle an expanded role on defense versus the Jaguars in the event that Poyer can't go.

Bills head coach Sean McDermott said Friday that Poyer (hamstring) is ruled out for Sunday's regular-season finale against the Jets, Maddy Glab of the team's official site reports.

EDGE Analysis

Poyer will miss a second consecutive contest to close out the regular season. Buffalo will hope to have the starting safety back on the field in time for the wild-card round of the AFC playoffs. Across his 10 regular-season appearances in 2025, Poyer racked up 70 tackles (31 solo), including 0.5 sacks, plus three passes defensed, including one interception.

Poyer (hamstring) won't participate in Wednesday's walkthrough practice, Maddy Glab of the Bills' official site reports.

EDGE Analysis

The 34-year-old was sidelined for the Week 17 loss to the Eagles due to a hamstring issue, and Wednesday's DNP suggests he's still dealing with the injury. Poyer likely needs to upgrade to full practice Thursday or Friday to avoid carrying an injury designation in Sunday's matchup against the Jets, though he may be rested with the Patriots having already secured the AFC East title.

Poyer (hamstring) has been ruled out for Sunday's game against Philadelphia, Maddy Glab of the Bills' official site reports.

EDGE Analysis

Poyer suffered a hamstring injury last Sunday against Cleveland. In his return to Buffalo this season, the veteran safety been an integral part of the Bills' defense, starting nine of 10 games since making his season debut Week 6. It's unclear who will replace Poyer as a starter Sunday, but that role could go to either veteran Darnell Savage or rookie Jordan Hancock.

Poyer (hamstring) was a non-participant in Wednesday's walkthrough practice.

EDGE Analysis

The veteran from Oregon State was deemed day-to-day with a hamstring issue following the Week 16 win over the Browns, so Wednesday's DNP comes as no surprise. Poyer has been an integral part of Buffalo's secondary this season, recording 70 total tackles and three passes defensed, including an interception, over 10 appearances. If he's sidelined for the Week 17 matchup against the Eagles, Jordan Hancock will likely operate as the Bills' top strong safety.