Brown (hamstring) has been ruled out for Saturday's NFC divisional-round clash against the Seahawks, Briana Jeannel of the 49ers' official site reports.

EDGE Analysis

Brown was unable to practice all week due to a hamstring injury he sustained during the 49ers' wild-card win over the Eagles on Sunday. With Brown sidelined, Marques Sigle figures to be the top candidate to start at safety alongside Malik Mustapha while Jason Pinnock and Siran Neal provide depth at the position.

Brown (hamstring) did not participate at practice Wednesday, Cam Inman of The San Jose Mercury News reports.

EDGE Analysis

Brown was estimated as a non-participant when the 49ers started their preparations for the Divisional Round with a walkthrough practice Tuesday, and he couldn't take any reps when the club ran a full practice Wednesday. Unless he can get back on the practice field Thursday, he'll be on track to spend Saturday's game at Seattle on the sidelines.

Brown (hamstring) did not participate in Tuesday's walkthrough practice, Nick Wagoner of ESPN.com reports.

EDGE Analysis

Brown injured his hamstring during the first half of the 49ers' 23-19 win over the Eagles during Sunday's NFC wild-card game, finishing the contest with four tackles (two solo). The 2023 third-rounder will have two more opportunities to return to practice ahead of Saturday's divisional-round clash against the Seahawks.

Brown (hamstring) has been ruled out for the remainder of Sunday's contest against Philadelphia, Nick Wagoner of ESPN.com reports.

EDGE Analysis

Brown suffered a hamstring injury late in the first half, and his night has now officially come to a premature end. Marques Sigle will continue to see an increase in workload in San Francisco's secondary with Brown unavailable.

Brown (hamstring) is questionable to return to Sunday's contest against the Eagles, Eric Branch of the San Francisco Chronicle reports.

EDGE Analysis

Brown suffered a hamstring injury in the second quarter of the team's matchup with Philadelphia in the wild-card round. In his absence, Jason Pinnock and Marques Sigle are top candidates to see added snaps at safety.

Brown had 76 tackles (44 solo), two interceptions and one forced fumble in 17 regular-season starts with the 49ers in 2025.

EDGE Analysis

Brown's versatility was on full display in 2025 when he was asked to move over to strong safety in Week 6 after teammate Malik Mustafa returned from injury. The 25-year-old Brown wasn't affected by the shift when he finished the regular season with one less combined tackle and one more interception than he did in 2024. Brown will enter the final year of his rookie contract starting at one of San Francisco's safety positions while providing a solid floor for IDP fantasy managers.

Brown registered four tackles (one solo) and one pass defense during the 49ers' 42-38 win over the Bears on Sunday.

EDGE Analysis

Brown played all 66 defensive snaps during Sunday's win but had just four stops to show for it. It was just the third time he's logged four tackles or less since taking over as the starting safety in Week 6 against the Buccaneers. The third-year pro is up to 68 tackles (39 solo), six pass defenses (two interceptions) and one forced fumble through 16 regular-season games.

Brown tallied nine tackles (five solo) and forced a fumble Sunday in a 48-27 win against the Colts.

EDGE Analysis

Brown tied for the 49ers' lead in tackles, with three of his stops coming on special teams. He also forced a fumble that was recovered the San Francisco as part of that unit, setting up his team's second touchdown of the game. Brown's nine total stops were his second-most in a game this season, topped only by the 10 tackles he recorded in Week 10 against the Rams.

Brown recorded five tackles (four solo) and two interceptions in Monday night's win over the Panthers.

EDGE Analysis

Brown played all 46 defensive snaps for San Francisco and recorded his first two interceptions of the season. Brown's first interception of Bryce Young came on a first-quarter pass into the end zone intended for Mitchell Evans. The second was a fourth-quarter pass intended for Tetairoa McMillan over the middle. On the season, Brown has logged 48 tackles (28 solo) and five pass breakups, including the two interceptions.

Brown tallied seven tackles (three solo) in San Francisco's win over the Cardinals on Sunday.

EDGE Analysis

Brown finished tied for third on the team in tackles in the victory. The 25-year-old has been on a hot streak over the past two weeks, recording a combined 17 tackles (six solo). He'll look to carry this level of production into the Week 12 matchup versus the Panthers.