Cook took 20 carries for 74 yards and had one reception on four targets for three yards in Sunday's 13-12 loss to Philadelphia.

EDGE Analysis

Cook reached the 20-carry mark for the sixth time this season, but unlike the previous five occurrences, he failed to hit the century mark in rushing yards against the Eagles. It was also just the fourth time in 2025 that the star running back was held below 4.0 yards per carry. While the Georgia product isn't known for his work as a receiver, finishing with more targets (four) than receiving yards (three) certainly feels like a letdown. It has been an incredible overall campaign from Cook so far through 16 starts (307-1,606-12), so he will look to finish the regular season on a high note in a soft matchup against the Jets in Week 18.

Cook carried the ball 16 times for 117 yards and two touchdowns during Buffalo's 23-20 win over Cleveland on Sunday. He also secured one of two targets for 17 yards.

EDGE Analysis

Cook has now surpassed 100 rushing yards in back-to-back games, as well as four of his last five appearances. He did much of his damage versus the Browns in the first half, scoring on a highlight-reel 44-yard run early in the first quarter, before finding pay dirt from three yards out late in the second quarter. Cook remains entrenched as the focal point of Buffalo's offense and is locked in as a high-end RB1 for fantasy purposes heading into a home matchup against the Eagles in Week 17. The Bills then will close out the regular season with a favorable home game against the Jets in Week 18.

Cook rushed 22 times for 107 yards and two touchdowns while bringing in two of three targets for four yards and another score in the Bills' 35-31 win over the Patriots on Sunday.

EDGE Analysis

Facing a notoriously stingy Patriots run defense, Cook carefully picked his spots throughout the afternoon and consistently churned out productive gains. He was a critical contributor to the Bills' second-half rally, recording three- and 11-yard touchdown runs. Those scoring scampers were preceded by a five-yard scoring grab with just under two minutes remaining in the first half, giving Cook his first three-TD tally of the season. The star running back figures to be heavily involved again in a Week 16 road matchup against the Browns next Sunday.

Cook carried the ball 18 times for 80 yards and caught both his targets for 31 yards in Sunday's 39-34 win over the Bengals.

EDGE Analysis

The star running back had a little trouble holding onto the ball in snowy, cold conditions, committing two fumbles and losing one, but he reached 100 scrimmage yards for a fourth straight game and the sixth time in the last seven contests. Over that stretch, Cook has piled up 771 rushing yards and three TDs on the ground while adding a 17-178-1 line on 17 targets. He'll face a much tougher test in Week 15 against the Patriots' stingy run defense.

Cook took 32 carries for 144 yards and a lost fumble while bringing in all three of his targets for 33 yards in Sunday's 26-7 win over Pittsburgh.

EDGE Analysis

Cook set new season highs in carries and touches while gashing the Steelers' defense for 177 yards on the road. Buffalo's workhorse also finished as the team's leading receiver while accounting for 48 percent of the offense's net yards Sunday. The only blemish on yet another dominant rushing performance was a pair of fumbles, only one of which was scooped up by the defense. Cook had coughed up just one fumble over his previous 11 contests, which looks minuscule standing next to the nine touchdowns and 1,464 yards from scrimmage the fantasy stud has provided managers this season. A tasty matchup against the Bengals' defense awaits Cook and the Bills in Week 14.

Cook rushed 17 times for 116 yards and a touchdown while bringing in all three targets for 13 yards in the Bills' 23-19 loss to the Texans on Thursday night.

EDGE Analysis

Cook managed his sixth 100-yard effort on the ground this season while posting his first rushing touchdown since Week 8 via a 45-yard run to cap off Buffalo's opening possession of the contest. The star running back continued to consistently generate solid gains against a tough Texans defense the rest of the night as well, and the productive performance locked in his third consecutive 1,000-yard rushing season. Cook next takes aim at the Steelers' inconsistent run defense in a Week 13 road matchup on Sunday, Nov. 30.

Cook rushed 16 times for 48 yards and secured all three targets for 66 yards in the Bills' 44-32 win over the Buccaneers on Sunday.

EDGE Analysis

Cook unsurprisingly found running room at a premium against a stingy Buccaneers front, but he was able to salvage his fantasy day with his best work of the season as a receiver. The fourth-year pro contributed a 25-yard touchdown reception on his three catches, and he finished with a season-high receiving yardage total. The going doesn't get any easier for Cook in Week 12, however, as the Bills face a tough Texans defense on the road in a Thursday night matchup.

Cook rushed 13 times for 53 yards and brought in all five targets for 24 yards in the Bills' 30-13 loss to the Dolphins on Sunday. He also lost a fumble.

EDGE Analysis

Cook was involved as a receiver at his highest clip since Week 1, as the Bills were already down 16-0 at halftime and therefore were in catch-up mode throughout the second half. The talented back did run hard with his limited opportunities on the ground, but he finished tied for a season low in carries and also lost a fumble in Dolphins territory early in the second quarter that helped lead to a Miami field goal. The downturn was drastic after Cook had rushed for 330 yards and two touchdowns over the previous two games, but he'll look to bounce back in Week 11 at home against a typically stingy Buccaneers run defense that showed some cracks against the Patriots' TreVeyon Henderson on Sunday.

Cook (ankle) doesn't have a designation for Sunday's game at Miami.

EDGE Analysis

After Cook sat out Wednesday's practice due to a foot injury, coach Sean McDermott told Alaina Getzenberg of ESPN.com that the running back's health concern emerged during this past Sunday's win against the Chiefs and that he'd been sore in the meantime. Cook followed up Wednesday's DNP with a limited session Thursday and a full practice Friday, thereby clearing him for Week 10 action. He'll be facing a Dolphins defense Sunday against whom he went for 118 yards from scrimmage and one rushing TD on 22 touches back in Week 3.

Cook (ankle) was limited at practice Thursday.

EDGE Analysis

On the heels of logging a 'DNP' on Wednesday, Cook is trending in the right direction ahead of Sunday's game against the Dolphins after returning to a capped session one day later. The Bills' top RB now will have one more chance to upgrade his participation level before the team assigns Week 10 injury designations Friday.