Isaiah McGuire
EDR/DE CLE (9)
Sun 12/7/25 12:22 PM

McGuire (knee) is active for Sunday's game against the Titans.
EDGE Analysis
McGuire had his practice reps limited during Week 14 prep due to a knee injury, but the third-year defensive end has been cleared to play Sunday after going through pregame warmups. He has accumulated 29 tackles (17 solo), including 2.0 sacks, and one forced fumble through 12 regular-season games.

Isaiah McGuire
EDR/DE CLE (9)
Fri 12/5/25 5:37 PM

McGuire (knee) is listed as questionable for Sunday's game against the Titans, Chris Easterling of the Akron Beacon Journal reports.
EDGE Analysis
McGuire was a non-participant in Wednesday's practice before stringing consecutive limited sessions together to end the week. The consistent participation means the defensive end is likely trending towards suiting up for Sunday. If the 24-year-old is unable to go, Cameron Thomas would be in line to see more rotational snaps at defensive end.

Isaiah McGuire
EDR/DE CLE (9)
Mon 11/24/25 10:39 PM

McGuire posted seven tackles (four solo), including 1.0 sacks, and two QB hits during the Browns' 24-10 win over the Raiders on Monday.
EDGE Analysis
McGuire got to Geno Smith twice during Sunday's win, with the former splitting sacks with Mike Hall and Cameron Thomas in the third and fourth quarter, respectively. McGuire's seven stops were a season high, and the third-year defensive end is up to 28 tackles (17 solo), including 2.0 sacks, and one forced fumble through 11 regular-season games.

Isaiah McGuire
EDR/DE CLE (9)
Thu 11/6/25 7:32 PM

McGuire (illness) logged a full practice session Thursday, Daniel Oyefusi of ESPN.com reports.
EDGE Analysis
McGuire missed Wednesday's practice due to an illness, but he was back and able to participate in full one day later. As such, the third-year defensive end should be good to go against the Jets on Sunday.

Isaiah McGuire
EDR/DE CLE (9)
Wed 11/5/25 7:17 PM

McGuire did not participate in Wednesday's practice due to an illness, Mary Kay Cabot of The Cleveland Plain Dealer reports.
EDGE Analysis
McGuire is under the weather to start Week 10 prep, but he'll have two more opportunities to return to practice ahead of Sunday's game against the Jets. The third-year defensive end has logged 16 tackles (10 solo), including 1.0 sacks, and one forced fumble through eight regular-season games.

Isaiah McGuire
EDR/DE CLE (9)
Fri 1/10/25 11:55 AM

McGuire racked up 36 tackles (18 solo), including 2.5 sacks, plus three forced fumbles across 16 regular-season appearances with the Browns in 2024.
EDGE Analysis
McGuire ramped up his involvement on defense Year 2, managing to close out the campaign as a clear starter. The 2023 fourth-round pick suited up for just four games as a rookie, but he's now demonstrated a legitimate ability to contribute on defense. He'll spend the offseason looking to further his development in Cleveland's scheme.

Isaiah McGuire
EDR/DE CLE (9)
Tue 8/8/23 8:00 AM

McGuire will be given chances on the second team defense after injuries to defensive end Alex Wright (knee) and Isaiah Thomas (knee), Zac Jackson of The Athletic reports.
EDGE Analysis
McGuire, a rookie drafted in the fourth round, lined up with the twos Monday, as did Sam Kamara. The Browns feel good about the top three ends -- Myles Garrett, Za'Darius Smith and Ogbonnia Okoronkwo -- but new defensive coordinator Jim Schwartz planned to utilize a bunch of different pass rushers. Both Thomas and Wright are expected to miss extended time.