Karlaftis accumulated 48 tackles (25 solo), including 6.0 sacks, two pass defenses and one fumble recovery across 16 games in 2025 with the Chiefs.

EDGE Analysis

The fourth-year pro looked like he was on his way to a career year after opening the season with 4.5 sacks and 20 combined tackles through the first five games of the regular season. Karlaftis wasn't able to carry that momentum for the rest of 2025, but his combined tackles were one more than his previous career high set in 2023 across (16 regular-season games). The 2022 first-rounder signed a four-year, $93 million contract extension in July and will be a cornerstone of the Chiefs' defense for years to come.

Karlaftis (rest) is inactive for Sunday's contest against the Raiders, Matt McMullen of the Chiefs' official site reports.

EDGE Analysis

Karlaftis will get a breather in the regular-season finale with Kansas City already eliminated from the postseason. In his absence, Charles Omenihu is a top candidate to take over as a starter on the defensive line versus Las Vegas.

Karlaftis (rest) is listed as questionable ahead of Sunday's game against the Raiders.

EDGE Analysis

Karlaftis was a limited participant throughout Week 18, but his injury status is listed as non-injured rest. The defensive end signed a four-year, $93 million contract with the Chiefs in July. The team may just be looking to protect a valuable asset ahead of the 2026 season, as Kansas City missed the playoffs for the first time since the 2014 campaign. If Karlaftis is inactive for Sunday's game, he will end the season with 48 tackles (25 solo), including 6.0 sacks, and two passes defensed through 16 games.

Karlaftis (illness) is active for Thursday night's game against the Broncos.

EDGE Analysis

Karlaftis will be good to go for Week 17 after being added to the injury report with an illness Wednesday. The defensive lineman has compiled 46 total tackles (24 solo), including 6.0 sacks, while also adding two passes defensed and a fumble recovery over 15 games so far this year.

Karlaftis (illness) is listed as questionable for Thursday's game against Denver.

EDGE Analysis

Karlaftis popped up on Wednesday's injury report as a limited practice participant due to an illness, which puts him in jeopardy of playing Christmas Day. Charles Omenihu, Ashton Gillotte, Mike Pennel and Jerry Tillery would be in line for larger rotational roles on the defensive line if one or both of Karlaftis and Derrick Nnadi (illness) were unable to play.

Karlaftis (thumb) has no injury designation ahead of Sunday's matchup against the Broncos.

EDGE Analysis

The Purdue product upgraded from limited practice sessions Wednesday and Thursday to a full go Friday, indicating that he's moved past his thumb injury in time to play in the Week 11 divisional matchup. Now fully healthy, expect Karlaftis to operate as one of Kansas City's top defensive linemen Sunday.

Karlaftis (thumb) was a limited participant at practice Wednesday.

EDGE Analysis

Karlaftis led Chiefs defensive ends in defensive snaps (51) in the last game before their Week 10 bye at Buffalo, and it's not immediately obvious when he suffered the thumb injury. He'll have two more opportunities to practice in full before Kansas City publishes its final practice report of the week Friday.

Karlaftis recorded three total tackles (one solo), including 1.0 sacks, and a pass defensed in Monday night's 28-7 win over the Commanders.

EDGE Analysis

Karlaftis was able to get to Marcus Mariota in the first quarter, securing his first full sack since Week 4. The defensive lineman has now registered 26 total tackles (16 solo), including 4.5 sacks, while also adding two passes defensed and a fumble recovery over eight games this year.

Karlaftis recorded two total tackles (one solo), including 0.5 sacks, while also recovering a fumble in Monday's 31-28 loss to Jacksonville.

EDGE Analysis

Karlaftis was held to two tackles for the second straight week, but he was still able to combine with Leo Chenal to sack Trevor Lawrence in the fourth quarter. Additionally, he was able to hop on loose ball after Nick Bolton stripped Lawrence in the second quarter, notching his first fumble recovery since 2022. Karlaftis has now registered 20 total tackles (14 solo), including 3.5 sacks, while also adding a pass defensed and a fumble recovery over five games this year.

Karlaftis recorded two tackles (two solo), including 1.0 sacks, in the Chiefs' win over the Ravens on Sunday.

EDGE Analysis

Karlaftis has been extremely disruptive through four games to begin the season, as he's already up to 18 tackles (13 solo), including 3.0 sacks and six TFLs, 10 QB hits and one pass breakup on 88 percent of the defensive snaps for Kansas City. Only Nik Bonitto has logged more QB hits (11) than Karlaftis through four games.