The 49ers activated Middleton (undisclosed) from the practice squad injured list Wednesday, Keiana Martin of the 49ers' official site reports.

EDGE Analysis

Middleton had been sidelined since early December with an unspecified injury. He hasn't yet appeared in a game during the 2021 campaign but will be able to return to practice ahead of Sunday's wild-card matchup against the Cowboys.

Middleton (undisclosed) was placed on the practice squad injured list Thursday.

EDGE Analysis

San Francisco used the spot opened up by this move to sign fellow safety Kai Nacua to its practice squad. The nature of Middleton's injury hasn't been revealed.

The Jaguars cut Middleton on Wednesday, James Palmer of NFL Network reports.

EDGE Analysis

Middleton only handled five defensive snaps across 10 appearances with the Jaguars last season, as compared to 190 special-teams snaps. The veteran safety will look for a depth role elsewhere in the league.

The Jaguars signed Middleton to the active roster Saturday.

EDGE Analysis

Middleton has geared up three times for Jacksonville this year, but he's played exclusively on special teams. His defensive role could grow moving forward, however, as starting safety Josh Jones (chest) was placed on injured reserve Saturday.

Middleton was promoted to Jacksonville's active roster from the practice squad Saturday.

EDGE Analysis

The 27-year-old joined the practice squad in early October after being cut by the Jags, but he's now back on the active roster. Middleton has exclusively played special teams in his two appearances this season and could have a similar role Sunday against Houston.

The Jaguars activated Middleton off the practice squad COVID-19 list Thursday.

EDGE Analysis

Middleton is one of 11 players cleared to return from the COVID-19 list for Jacksonville on Thursday. He's eligible to immediately resume participating in practice squad activities.

Middleton was placed on the practice squad reserve/COVID-19 list by the Jaguars on Saturday.

EDGE Analysis

Middleton has either tested positive for the virus or come into close contact with an infected person. In order to return to team activities, the Appalachian State product will need to pass the league's COVID-19 protocols.

Middleton was cut by the Jaguars on Monday, per the NFL's official transaction log.

EDGE Analysis

Middleton was promoted from the practice squad for Sunday's loss to the Bengals and played 17 snaps on special team. The 27-year-old could return to the Jags' practice squad if he's unable to find a job elsewhere.

The Titans signed Middleton to a contract Wednesday, Jim Wyatt of the team's official site reports.

EDGE Analysis

The Titans cut waived offensive lineman Avery Gennesy to make room for Middleton on the roster. The 26-year-old safety will have just a few days to compete for a depth role before Tennessee cuts down to the final team.

Middleton was waived by Jacksonville on Saturday.

EDGE Analysis

Middleton received a late-season promotion from the practice squad and played special teams for the final two games of the 2019 season. The 26-year-old had 27 tackles in seven games with the Jets in 2018, but he split last season between the Dolphins and Jaguars, and he's once again in search of a new team.