Henderson (illness) rushed four times for 16 yards and hauled in both of his targets for 14 yards in Sunday's 31-14 loss to the 49ers.

EDGE Analysis

Henderson was able to suit up after dealing with an illness during practice this week. The 25-year-old was expected to lead a depleted Rams backfield, but he finished with less touches than Ronnie Rivers (15) and just one more than Malcolm Brown (5/10/0). With Cam Akers (personal) sidelined and seeking a trade, the Rams' running back situation is one best left alone until someone steps up and grabs the vacant lead role. For now, we have to consider Henderson as one part of an unappealing committee situation heading into a matchup against Tampa Bay next Sunday.

Henderson (illness) doesn't have an injury designation for Sunday's game against the 49ers, Jourdan Rodrigue of The Athletic reports.

EDGE Analysis

Henderson was sick earlier in the week, missing practice Wednesday and returning as a limited participant Thursday. He turned in a full practice Friday, setting him up to lead the Rams backfield against a tough 49ers defense this Sunday. With Cam Akers (personal) held out again and facing an uncertain future, the Rams are likely to rely on Henderson as their starter and Malcolm Brown as the No. 2 back. There has been talk of the team trading away Akers and seeking a replacement, but that won't interfere with Henderson's Week 8 workload.

Henderson (illness) practiced in a limited capacity Thursday, Gilbert Manzano of The Orange County Register reports.

EDGE Analysis

One day removed from sitting out of drills entirely due to an illness, Henderson unsurprisingly returned to the field with a cap on his reps Thursday. With Cam Akers (personal) away from the team for the time being, a healthy and active Henderson is the Rams' top running back, but first he'll need to ditch his designation ahead of Sunday's game against the 49ers, which may happen as soon as the release of Friday's injury report.

Henderson (illness) returned to practice Thursday, Jourdan Rodrigue of The Athletic reports.

EDGE Analysis

Absent Wednesday due to an illness, Henderson was able to mix back into drills in some capacity one day later, which bodes well for his availability as the Rams prepare for Sunday's matchup with the 49ers. His activity level Thursday will reveal where his health stands at the moment.

Henderson didn't practice Wednesday due to an illness, Matt Barrows of The Athletic reports.

EDGE Analysis

Henderson wasn't spotted on the field for the media-access portion of Wednesday's session, and the reason for his absence now is known. With Cam Akers (personal) also not slated to practice this week, Malcolm Brown was the only running back on the active roster taking part, while Kyren Williams (ankle) joined him after the Rams designated him for return from IR on Wednesday. Henderson will have two more days to return to drills before the team potentially gives him a designation for Sunday's game against the 49ers.

Henderson isn't on the field for the open portion of Wednesday's practice, Gary Klein of the Los Angeles Times reports.

EDGE Analysis

An injury coming out of the bye week would be the latest interesting development in a Rams backfield that remains without Cam Akers (personal) and saw rookie Kyren Williams (ankle) designated Wednesday to return from injured reserve. It's possible Henderson is simply being rested or dealing with a minor injury; the Wednesday injury report should provide some idea once the Rams are finished practicing.

Henderson carried the ball 12 times for 43 yards and a touchdown and caught two of three targets for nine yards in Sunday's 24-10 win over the Panthers.

EDGE Analysis

With Cam Akers (personal) seemingly on his way out of town, Henderson sits unchallenged at the top of the Rams' depth chart, but his first start as the clear No. 1 was unproductive until he punched in a two-yard score midway through the fourth quarter to ice the game. The team's offensive line issues will cap his upside, but Henderson should at least see steady touch volume on the other side of the Rams' Week 7 bye.

Henderson is expected to serve as the Rams' lead back Sunday against the Panthers with Cam Akers (personal) having been ruled out for the Week 6 game, Sarah Barshop of ESPN.com reports.

EDGE Analysis

Head coach Sean McVay declined to go in specifics regarding why Akers didn't practice with the team Thursday or Friday, nor did McVay give a direct answer regarding Akers' status with the team moving forward. At least for Week 6, Akers' absence should pave the way for Henderson to handle a larger share of the backfield work after the latter had typically operated as a change-of-pace option while handling snap shares between 50 and 60 percent in each of the past three weeks. In addition to remaining the Rams' top pass-catching option out of the backfield, Henderson should take on more of Akers' vacated early-down work, though veteran Malcolm Brown could also take on a portion of those duties. Regardless, Henderson's expected increase in usage looks like it could be enough to make him a viable starting running back or flex option in the majority of fantasy leagues during Week 6.

Henderson caught four of five targets for 30 yards in Sunday's 22-10 loss to the Cowboys.

EDGE Analysis

Despite being on the field for nearly double the amount of snaps as Cam Akers on Sunday, Henderson only logged a single rushing attempt on the day, and that was negated by an offensive holding penalty on Ben Skowronek. The Rams used Henderson as a receiving back for the majority of his time on the field, and while the results weren't inspiring, Akers struggled as well, turning his 13 rushing attempts into a paltry 33 yards. Week 6 brings relief in the form of a Panthers team that just gave up 199 yards from scrimmage and three TDs to 49ers running backs Jeff Wilson and Tevin Coleman.

Henderson rushed seven times for 27 yards and caught three of four targets for 12 yards in Monday's 24-9 loss to San Francisco.

EDGE Analysis

Cam Akers got the start but mustered just 13 scrimmage yards on eight carries and one target. Henderson appears to be the team's running back of choice when negative game scripts lead to more passing situations, and that could be the case in Week 5 against a Cowboys team that's riding a three-game winning streak.