Aiyuk (shoulder) is listed as inactive Thursday against the Giants, Lindsey Pallares of the 49ers' official site reports.

EDGE Analysis

Aiyuk played through a left shoulder injury during the 49ers' Week 2 win at the Rams, handling 30 of 57 offensive snaps on his way to three catches (on six targets) for 43 yards. He proceeded to be listed as a non-participant on Monday's practice estimate before capping Week 3 prep with back-to-back limited listings. Adam Schefter of ESPN reported Thursday afternoon that Aiyuk was unlikely to suit up versus New York, and indeed that has come to pass. With Aiyuk sidelined, Jauan Jennings is the top candidate to absorb the former's typical workload alongside Deebo Samuel, but rookie Ronnie Bell, Ray-Ray McCloud and practice-squad call-up Chris Conley also may get in the WR mix for San Francisco.

Aiyuk (shoulder), who is listed as questionable for Thursday's game against the Giants, isn't expected to play, Adam Schefter of ESPN reports.

EDGE Analysis

Aiyuk's status will be confirmed approximately 90 minutes prior to the 8:15 p.m. ET kickoff, when the 49ers release their inactive list. With Aiyuk on track to miss the Week 3 contest, Jauan Jennings, Ronnie Bell and Ray-Ray McCloud could be all be in store for expanded opportunities in both two- and three-receiver sets, though No. 1 wideout Deebo Samuel, tight end George Kittle and running back Christian McCaffrey profile as quarterback Brock Purdy's top three options in the passing game.

Aiyuk (shoulder) is listed as questionable for Thursday's game against the Giants, Jennifer Lee Chan of NBC Sports Bay Area reports.

EDGE Analysis

The 49ers posted practice estimates Monday and Tuesday, which included Aiyuk as a non-participant on the first one and a limited participant on the second. He was able to play through a left shoulder injury that he suffered early on in this past Sunday's road win against the Rams, logging 52 percent of the offensive snaps en route to three catches (on six targets) for 43 yards. Aiyuk's availability Thursday will become known about 90 minutes before an 8:15 p.m. ET kickoff, but if he's inactive for the contest or available to play only limited snaps, Jauan Jennings and Ronnie Bell would stand to benefit behind Deebo Samuel.

San Francisco head coach Kyle Shanahan said Aiyuk (shoulder) will be a limited participant in Tuesday's practice, Nick Wagoner of ESPN.com reports.

EDGE Analysis

Aiyuk had been listed as a non-participant on Monday's estimated practice report, but the receiver will apparently be able to log some reps Tuesday when the 49ers actually take the field. Because the 49ers are facing a quick turnaround from this past Sunday's win over the Rams, Aiyuk may not have enough time to fully move past his left shoulder injury ahead of Thursday's game agains the Giants. At this stage of the week, Shanahan labeled Aiyuk as a game-time decision ahead of Thursday's 8:15 p.m. ET kickoff.

Aiyuk (shoulder) was listed as a non-participant on Monday's practice estimation, Cam Inman of The San Jose Mercury News reports.

EDGE Analysis

Per Lindsey Pallares of the 49ers' official site, a left shoulder injury kept Aiyuk out for a select number of plays during Sunday's 30-23 win over the Rams, so the wideout's status will need to be monitored as Thursday night's game against the Giants approaches. In the 30 snaps on offense (out of a possible 57) that Aiyuk logged versus Los Angeles, the 49ers' starting WR caught three of his six targets for 43 yards.

Head coach Kyle Shanahan announced that Aiyuk suffered a shoulder injury in Sunday's win over the Rams that limited his playing time, according to 49ers' team reporter Lindsey Pallares.

EDGE Analysis

Aiyuk was able to finish the game and post a final line of three catches on six targets for 43 yards. The 25-year-old suffered the shoulder injury in the first quarter and was seen being worked on by trainers at various points of contest. Aiyuk didn't appear limited when he would return to action, which is a positive sign for his availability moving forward. That said, it wouldn't be surprising to see Aiyuk's name pop up on the injury report with a Thursday matchup against the Giants on tap for Week 3.

Aiyuk caught all eight of his targets for 129 yards and two touchdowns in Sunday's 30-7 win over the Steelers.

EDGE Analysis

Aiyuk capped San Francisco's first possession of the season with an eight-yard touchdown catch, then made a contested catch with cornerback Patrick Peterson draped all over him in the front corner of the end zone for a 19-yard touchdown in the second quarter. He accounted for both of Brock Purdy's touchdown passes as the 49ers excelled in all phases in Week 1. Aiyuk had 1,015 yards and eight touchdowns in 2022, so he's already a quarter of the way to last season's TD total heading into a Week 2 road game against the Rams.

Aiyuk caught one of three targets for 35 yards in Friday's preseason game against the Chargers.

EDGE Analysis

Aiyuk and Deebo Samuel each accounted for three of Brock Purdy's nine pass attempts as the 49ers' starters easily made their way down the field against the Chargers' backups. Things might not look so easy Week 1 at Pittsburgh, though the cornerbacks are probably the relative weak point of an otherwise stellar Steelers defense.

Aiyuk hauled in his lone target for 15 yards in Saturday's 21-20 preseason win over Denver.

EDGE Analysis

Aiyuk got his first taste of action this preseason along with the rest of the starting wideouts Saturday. San Francisco also welcomed back starting quarterback Brock Purdy (elbow) from injury, who found Aiyuk for a 15-yard gain on the first-team offense's lone drive. The 2020 first-round pick blossomed into a reliable fantasy option last season after posting a career-best 78-1,015-8 receiving line across 17 games. Deebo Samuel is still the 49ers' top option at wide receiver, but Aiyuk could narrow that gap if he takes another step forward heading into the fourth and final year of his rookie contract.

Aiyuk is in uniform for Saturday's preseason contest versus the Broncos, Eric Branch of the San Francisco Chronicle reports.

EDGE Analysis

With Brock Purdy expected to see his first game action since he injured his right throwing elbow in last season's NFC Championship Game loss in Philadelphia, he's slated to have his top two wide receivers available in Aiyuk and Deebo Samuel. In the upcoming campaign, Aiyuk will be looking to replicate his breakout 2022 in which he hauled in 78 passes for 1,015 yards and eight touchdowns in 17 contests.