A.J. Epenesa
EDR/DE BUF (7)
Thu 1/15/26 2:44 PM

Epenesa (neck) has no injury designation ahead of Saturday's divisional-round matchup against the Broncos.
EDGE Analysis
The 27-year-old from Iowa practiced in a limited fashion throughout the week, but it now appears he's moved past his neck injury in time to play Saturday. Epenesa operated as one of Buffalo's top defensive ends during the regular season, recording 32 total tackles, including 2.5 sacks, and four passes defensed, with two interceptions, over 16 appearances. Back at full health, he's expected to play behind Joey Bosa and Greg Rousseau during the divisional-matchup in Denver.

A.J. Epenesa
EDR/DE BUF (7)
Wed 1/14/26 3:43 PM

Epenesa (neck) was a limited participant in practice Wednesday.
EDGE Analysis
Epenesa has been a limited participant in practice both Tuesday and Wednesday. The 27-year-old played his usual snap count (23) in the Bills' wild-card round matchup against the Jaguars, so it's unclear when his injury occurred. The six-year pro's status heading into the AFC divisional round will likely depend on his participation in practice Thursday.

A.J. Epenesa
EDR/DE BUF (7)
Fri 1/2/26 3:42 PM

Epenesa (illness) was a full participant in Friday's practice and does not carry an injury designation for Sunday's regular-season finale against the Jets.
EDGE Analysis
Epenesa popped up as a non-participant on Thursday's injury report due to an illness, but he appears to have already recovered from his ailment. A rotational defensive end, Epenesa could stand to handle an increased workload versus New York if Joey Bosa (hamstring), who is officially listed as questionable, doesn't play in Week 18.

A.J. Epenesa
EDR/DE BUF (7)
Thu 1/1/26 3:16 PM

Epenesa (illness) did not practice Thursday.
EDGE Analysis
Epenesa popped up on Thursday's injury report due to an illness and wasn't able to practice. His practice participation during Friday's session should shed light on his chances of playing in Sunday's regular-season finale against the Jets. He's worked in a rotational role at defensive end this season, so Javon Solomon would absorb more snaps on defense in the event that Epenesa doesn't play Week 18.

A.J. Epenesa
EDR/DE BUF (7)
Fri 12/5/25 3:20 PM

Epenesa (foot) has no injury designation ahead of Sunday's matchup against the Bengals.
EDGE Analysis
Head coach Sean McDermott told reporters Friday that Epenesa "should be fine" after he missed Thursday's practice due to a foot injury. Now fully healthy, Epenesa is likely to play an expanded role on the Bills' defensive line in Week 14, as Joey Bosa (hamstring) is in line to miss his first game of the season.

A.J. Epenesa
EDR/DE BUF (7)
Thu 12/4/25 5:12 PM

Epenesa (foot) did not practice Thursday, Alaina Getzenberg of ESPN.com reports.
EDGE Analysis
Epenesa was a new addition to Thursday's injury report with a foot injury he likely suffered during Wednesday's session. With the potential absence of Joey Bosa (hamstring) looming as well, Epenesa's absence will mean a significant depth issue at defensive end for the Bills. If neither player can suit up Sunday, Javon Solomon will be the lone option opposite Greg Rousseau on the edge. With such a depleted room, practice squad members Shaq Lawson, Andre Jones, and Morgan Fox are candidates for Week 14 elevation.

A.J. Epenesa
EDR/DE BUF (7)
Fri 11/14/25 3:43 PM

Epenesa (concussion) has no injury designation ahead of Sunday's matchup against the Buccaneers.
EDGE Analysis
Epenesa managed to practice in full the entire week and has been cleansed of injury designation, indicating he was able to clear the league's concussion protocol and is ready to play in Sunday's contest. Before missing the Week 10 loss to the Dolphins, the 27-year-old participated in eight games this season, where he accumulated 15 tackles (10 solo), including 2.5 sacks, two passes defensed, one interception and one fumble recovery. With Epenesa's return, defensive end Javon Solomon will likely see diminished snaps as a rotational end.

A.J. Epenesa
EDR/DE BUF (7)
Wed 11/12/25 7:40 PM

Epenesa (concussion) logged a full practice Wednesday, Alaina Getzenberg of ESPN.com reports.
EDGE Analysis
Epenesa missed Buffalo's Week 10 loss to Miami with a concussion. While it's encouraging that he returned to practice, it remains unclear whether he has cleared the league's concussion protocol. Epenesa will need to take that final step before being cleared for a Week 11 matchup against Tampa Bay.

A.J. Epenesa
EDR/DE BUF (7)
Fri 11/7/25 12:13 PM

Epenesa (concussion) won't play Sunday against the Dolphins, head coach Sean McDermott revealed Friday, Maddy Glab of the Bills' official site reports.
EDGE Analysis
Epenesa hasn't participated in practice throughout the week and will endure his first absence of the season Sunday. The rotational pass rusher has 2.5 sacks this season. Epenesa will need to clear the NFL's five-step concussion protocol to have a chance to play in Week 11 against the Buccaneers.

A.J. Epenesa
EDR/DE BUF (7)
Wed 11/5/25 7:08 PM

Epenesa (concussion) did not participate at practice Wednesday.
EDGE Analysis
Epenesa was quiet over 22 defensive snaps in Week 9 versus the Chiefs, but it's not clear if he suffered the concussion during that contest or sometime afterward. Either way, he'll need to clear league concussion protocol by Sunday in order to suit up at Miami in Week 10.