Santillan was optioned to Triple-A Louisville on Wednesday.

EDGE Analysis

The 24-year-old gave up three runs (two earned) over three innings Tuesday and will head to the minors with Sonny Gray (groin) slated to rejoin the rotation this weekend. According to C. Trent Rosecrans of The Athletic, Santillan is expected to rejoin the Reds and work out of the bullpen after spending the required 10 days in the minors.

Santillan (1-2) allowed three runs (two earned) on six hits and two walks while striking out four across three innings to take the loss Tuesday against San Diego.

EDGE Analysis

Santillan avoided disaster in the final outcome of his start, but he allowed multiple baserunners in all three innings that he worked. As a result, he needed 75 pitches to record his nine outs and has now failed to complete five innings in three of his four big-league starts. In total, Santillan has allowed seven earned runs across 16.2 innings with a 20:10 K:BB. With Sonny Gray (groin) projected to return to the rotation shortly, Santillan's role with the big-league club could set to change.

Santillan (1-1) allowed one earned run on three hits and three walks while striking out eight across six innings, earning the win over Atlanta on Thursday.

EDGE Analysis

Freddie Freeman got to Santillan early with a solo home run in the first inning. Other than that, it was smooth sailing for the rookie as he cruised to post a quality start in his first MLB win. The 24-year-old struck out eight batters in his third start, doubling his season total. He lowered his ERA to 3.29 over 13.2 innings. His next scheduled start is for Tuesday against the Padres.

Santillan (0-1) pitched only three innings while taking the loss in Friday's defeat to the Padres, allowing three runs on four hits, including two homers. He walked one and struck out three. He was lifted for a pinch hitter in the fourth inning with the Reds trying to tie the game with two outs.

EDGE Analysis

Manager David Bell went with the quick hook in this one to tie the game up, but it didn't work out, and then the Reds' bullpen got pounded for five runs afterward.

Santillan is scheduled to make his second start Friday against the Padres in San Diego.

EDGE Analysis

Neither Sonny Gray (groin) nor Jeff Hoffman (shoulder) will be ready to return from the 10-day injured list when the Reds next require a fifth starter Friday, so Santillan will be awarded another turn through the rotation after a so-so MLB debut against Colorado over the weekend. Though he limited the Rockies to one run, efficiency was an issue for Santillan, who pumped in only 52 of his 97 pitches for strikes while failing to make it out of the fifth inning. He'll need to show better control against a strong Padres offense if he hopes to continue keeping runs off the board.

Santillan didn't factor into the decision Sunday against the Rockies after giving up one run on five hits and four walks while fanning five across 4.2 innings.

EDGE Analysis

Santillan ended just one out away from securing the win in his MLB debut, though removing him with one out left in the fifth was probably the right decision considering he had walked two while also hitting Trevor Story in that same inning. Despite the command issues, it was a decent debut for Santillan, who took advantage of a favorable matchup against the Rockies away from Coors Field. He's expected to make another start next week and, tentatively, he'd line up to pitch in a far tougher matchup against the Padres on the road.

Santillan will start Sunday's game against the Rockies in Cincinnati.

EDGE Analysis

As expected, the 24-year-old right-hander will temporarily slot into the rotation as a replacement for Sonny Gray (groin), who is expected to miss at least two starts while he's on the injured list. Santillan excelled over his six starts at Louisville this season, posting a 2.45 ERA, 1.09 WHIP and a 45:12 K:BB in 32.1 innings. He'll draw a favorable matchup Sunday for his big-league debut against a Rockies offense that ranks last in the majors with a team-wide 58 wRC+ away from Coors Field this season.

Santillan was recalled by the Reds on Saturday.

EDGE Analysis

Santillan is expected to start Sunday against the Rockies for his big-league debut. He's gotten off to an excellent start for Triple-A Louisville, recording a 2.51 ERA and 34.4 percent strikeout rate through six starts.

Santillan will be called up to start Sunday against the Rockies for his major-league debut, Charlie Goldsmith of The Cincinnati Enquirer reports.

EDGE Analysis

Santillan will step into the rotation for at least one start with Sonny Gray (groin) and Jeff Hoffman (shoulder) both injured. He's not a particularly highly-rated prospect, though he's started this season well at Triple-A Louisville, posting a 2.51 ERA and a 34.4 percent strikeout rate through six starts.

Santillan is a potential candidate to get a spot start Friday for the Reds against the Cubs, with the team leading a pitcher to fill the gap until Wade Miley returns, Bobby Nightengale of The Cincinnati Enquirer reports.

EDGE Analysis

The Reds are off on Monday, giving Tyler Mahle, Jeff Hoffman and Sonny Gray their regular rest before needing a spot on Friday. Santillan has a 1.86 ERA over 19.1 innings spread over four starts at Triple-A Louisville. Vladimir Gutierrez is also on the 40-man roster at Louisville and could also make the start.