Santana is out of the lineup for Sunday's game against the Twins.

EDGE Analysis

Santana appears to be getting a well-earned rest for a day game. Kyle Manzardo will start at first base and C.J. Kayfus will serve as Cleveland's designated hitter.

Santana is not in the lineup for Tuesday's game against the Rockies.

EDGE Analysis

It looks to be a routine day off for Santana, who has just a .440 OPS so far in the second half. Kyle Manzardo will handle first base and David Fry will be the designated hitter for the Guardians.

Santana is out of the lineup for Thursday's game against the Orioles.

EDGE Analysis

Santana will get a standard veteran rest day while the Guardians and Orioles close out their four-game series with a matinee contest. With Santana on the bench, Kyle Manzardo will cover first base, while Jose Ramirez gets a day out of the infield and serves as the Guardians' designated hitter.

Santana went 1-for-4 with a walk, a two-run home run and a stolen base across both ends of Friday's doubleheader split with the White Sox.

EDGE Analysis

The veteran first baseman clubbed the game-winning homer in the matinee, breaking a 2-2 tie by taking Tyler Alexander deep in the sixth inning, and while Santana began the nightcap on the bench, he drew a walk as a pinch hitter and swiped a bag in the 10th inning. Four of his six steals on the year, and three of his 11 long balls, have come in his last 20 games, a stretch in which Santana is slashing just .171/.275/.314 with nine runs and 10 RBI.

Santana is out of the lineup for Friday's game against the Cardinals.

EDGE Analysis

Santana will yield to Kyle Manzardo at first base Friday, ending Santana's three-game start streak. The veteran first baseman is 13-for-77 (.169) with a pair of home runs in June.

Santana went 2-for-4 with a walk, a solo home run and a second run scored in Tuesday's 10-6 loss to the Blue Jays.

EDGE Analysis

The veteran switch hitter got the Guardians on the board in the sixth inning by taking Eric Lauer deep, Santana's ninth homer of the season. The multi-hit effort was his first in June, however, and through 19 games on the month he's slashing just .186/.230/.286 with two home runs and eight RBI.

Santana is out of the lineup for Sunday's game against the Athletics.

EDGE Analysis

Kyle Manzardo will cover first base and David Fry will serve as the Guardians' designated hitter while Santana receives his first day off since June 7. Since clubbing a grand slam in the Guardians' 11-2 win over the Reds on June 11, Santana has gone 4-for-31 with no extra-base hits over his last eight games, though he contributed two stolen bases during that stretch.

Santana went 1-for-4 with a grand slam in Wednesday's 11-2 win over the Reds.

EDGE Analysis

The veteran switch hitter broke the game open when he drove a Nick Lodolo changeup over the right-center field fence in the third inning. It was Santana's eighth homer of the season, but his first off a left-handed pitcher, while the grand slam was the sixth of his career among his 332 long balls. Through 63 contests in 2025, Santana is slashing .251/.350/.388 with 34 RBI, putting him on pace to reach 80 for only the second time since 2019.

Santana is not in the Guardians' starting lineup against the Astros on Saturday.

EDGE Analysis

Santana saw his 14-game hitting streak come to an end Friday when he went 0-for-4 with a strikeout in a 4-2 loss to Houston. He'll be in the dugout for the beginning of Saturday's game while Kyle Manzardo shifts to first base and bats fourth.

Santana went 2-for-4 with a solo home run in Saturday's 7-5 win over the Angels.

EDGE Analysis

Santana tied things up at 5-5 in the seventh inning, when he took Ryan Zeferjahn deep to right field for a solo home run. It was Santana's seventh home run of the season, five of which have come in May. He'll end the month with a .994 OPS with 18 runs scored and 22 RBI across 100 plate appearances.