| Team | | Time | Down | Distance | Pos | Description | Score | Max Pts |
|---|
| SF | 1st | 8:16 | 2nd | 28 | SF 31 | Deebo Samuel 13 yard Passing Completion from Jimmy Garoppolo Mike Hilton | 3-0 | 1.3 |
| SF | 4th | 12:47 | 2nd | 26 | SF 9 | Raheem Mostert 3 yard Rushing Attempt Bud Dupree | 13-17 | 0.3 |
| SF | 4th | 12:08 | 3rd | 23 | SF 12 | Raheem Mostert 10 yard Rushing Attempt Javon Hargrave | 13-17 | 1 |
| SF | 2nd | 8:04 | 2nd | 20 | PIT 21 | Matt Breida 5 yard Passing Completion from Jimmy Garoppolo Mike Hilton | 6-0 | 0.5 |
| SF | 2nd | 8:09 | 1st | 20 | PIT 21 | Jimmy Garoppolo Incomplete Pass to Jeff Wilson | 6-0 | |
| SF | 1st | 10:05 | 2nd | 19 | SF 28 | George Kittle 5 yard Passing Completion from Jimmy Garoppolo Devin Bush | 3-0 | 0.5 |
| SF | 4th | 2:47 | 2nd | 17 | PIT 20 | Richie James 6 yard Passing Completion from Jimmy Garoppolo Minkah Fitzpatrick | 20-17 | 0.6 |
| SF | 3rd | 13:28 | 2nd | 15 | SF 32 | Mason Rudolph Pass to JuJu Smith-Schuster Interception by K'Waun Williams JuJu Smith-Schuster | 6-3 | 2 |
| PIT | 3rd | 13:34 | 1st | 15 | PIT 32 | Mason Rudolph Incomplete Pass to Diontae Johnson | 6-3 | |
| SF | 2nd | 0:05 | 2nd | 15 | SF 15 | Matt Breida 5 yard Rushing Attempt Stephon Tuitt | 6-3 | 0.5 |
| SF | 2nd | 7:28 | 3rd | 15 | PIT 16 | Raheem Mostert 10 yard Rushing Attempt Devin Bush | 6-0 | 1 |
| SF | 1st | 7:38 | 3rd | 15 | SF 44 | George Kittle 8 yard Passing Completion from Jimmy Garoppolo Tyson Alualu | 3-0 | 0.8 |
| SF | 1st | 9:25 | 3rd | 14 | SF 33 | Richie James 16 yard Passing Completion from Jimmy Garoppolo Steven Nelson | 3-0 | 1.6 |
| PIT | 4th | 11:28 | 4th | 13 | PIT 22 | Ryan Switzer 0 yard Punt Return Attempt Emmanuel Moseley | 13-17 | |
| PIT | 4th | 0:41 | 4th | 12 | PIT 20 | Mason Rudolph Incomplete Pass to James Washington Jaquiski Tartt | 20-24 | |
| PIT | 2nd | 6:07 | 2nd | 12 | PIT 23 | James Conner 5 yard Rushing Attempt Jaquiski Tartt | 6-3 | 0.5 |
| PIT | 1st | 12:29 | 3rd | 12 | SF 35 | JuJu Smith-Schuster 7 yard Passing Completion from Mason Rudolph Tarvarius Moore | 0-0 | 0.7 |
| PIT | 1st | 4:52 | 2nd | 11 | PIT 27 | Jimmy Garoppolo Pass to Dante Pettis Interception by Minkah Fitzpatrick George Kittle | 3-0 | 2 |
| SF | 4th | 0:37 | 1st | 10 | PIT 20 | Jimmy Garoppolo -1 yard Rushing Attempt | 20-24 | -0.1 |
| PIT | 4th | 1:01 | 2nd | 10 | PIT 22 | Mason Rudolph 7 yard Rushing Attempt Kwon Alexander | 20-24 | 0.7 |
| PIT | 4th | 1:09 | 1st | 10 | PIT 22 | Mason Rudolph Incomplete Pass | 20-24 | |
| SF | 4th | 3:37 | 1st | 10 | PIT 13 | Jeff Wilson 3 yard Rushing Attempt Javon Hargrave | 20-17 | 0.3 |
| SF | 4th | 5:29 | 1st | 10 | PIT 24 | George Kittle 9 yard Passing Completion from Jimmy Garoppolo Terrell Edmunds | 20-17 | 0.9 |
| PIT | 4th | 5:36 | 1st | 10 | PIT 24 | James Conner Rushing Attempt Fumble Lost recovered by DeForest Buckner Zach Gentry | 20-17 | 1 |
| PIT | 4th | 6:49 | 1st | 10 | PIT 14 | James Conner 5 yard Rushing Attempt DeForest Buckner | 20-17 | 0.5 |
| SF | 4th | 8:53 | 1st | 10 | PIT 19 | Raheem Mostert 6 yard Rushing Attempt Joe Haden | 20-17 | 0.6 |
| SF | 4th | 9:47 | 1st | 10 | PIT 43 | Matt Breida 5 yard Rushing Attempt Devin Bush | 20-17 | 0.5 |
| SF | 4th | 10:22 | 1st | 10 | SF 25 | Matt Breida 7 yard Rushing Attempt Cameron Heyward | 20-17 | 0.7 |
| PIT | 4th | 10:28 | 1st | 10 | SF 39 | Diontae Johnson 39 yard Passing TD from Mason Rudolph | 19-17 | 9.9 |
| PIT | 4th | 11:18 | 1st | 10 | PIT 19 | James Conner 10 yard Rushing Attempt K'Waun Williams | 13-17 | 1 |
| SF | 4th | 14:01 | 1st | 10 | SF 25 | Matt Breida 3 yard Rushing Attempt Devin Bush | 13-17 | 0.3 |
| PIT | 3rd | 0:20 | 2nd | 10 | PIT 25 | Xavier Grimble 3 yard Passing Completion from Mason Rudolph Solomon Thomas | 13-17 | 0.3 |
| PIT | 3rd | 0:56 | 1st | 10 | PIT 25 | Benny Snell Rushing Attempt Kwon Alexander | 13-17 | |
| SF | 3rd | 2:17 | 1st | 10 | PIT 18 | Matt Breida 2 yard Rushing Attempt Joe Haden | 13-10 | 0.2 |
| SF | 3rd | 2:44 | 1st | 10 | PIT 29 | Deebo Samuel 11 yard Passing Completion from Jimmy Garoppolo Steven Nelson | 13-10 | 1.1 |
| SF | 3rd | 3:46 | 1st | 10 | PIT 44 | Raheem Mostert 5 yard Rushing Attempt Joe Haden | 13-10 | 0.5 |
| SF | 3rd | 4:33 | 1st | 10 | SF 36 | Deebo Samuel 20 yard Passing Completion from Jimmy Garoppolo Terrell Edmunds | 13-10 | 2 |
| SF | 3rd | 5:42 | 1st | 10 | SF 25 | Raheem Mostert 9 yard Rushing Attempt Terrell Edmunds | 13-10 | 0.9 |
| PIT | 3rd | 7:13 | 1st | 10 | PIT 18 | James Conner 1 yard Rushing Attempt DeForest Buckner | 6-10 | 0.1 |
| SF | 3rd | 7:59 | 2nd | 10 | SF 25 | Matt Breida 5 yard Rushing Attempt Devin Bush | 6-10 | 0.5 |
| SF | 3rd | 8:09 | 1st | 10 | SF 25 | Jimmy Garoppolo Incomplete Pass to Deebo Samuel | 6-10 | |
| PIT | 3rd | 9:08 | 2nd | 10 | PIT 22 | James Conner 5 yard Rushing Attempt Sheldon Day | 6-10 | 0.5 |
| PIT | 3rd | 9:11 | 1st | 10 | PIT 22 | Mason Rudolph Incomplete Pass to James Washington Richard Sherman | 6-10 | |
| SF | 3rd | 12:01 | 1st | 10 | PIT 27 | Raheem Mostert 2 yard Rushing Attempt Stephon Tuitt | 6-3 | 0.2 |
| SF | 3rd | 13:19 | 1st | 10 | PIT 38 | Matt Breida 5 yard Rushing Attempt Mark Barron | 6-3 | 0.5 |
| PIT | 3rd | 15:00 | 1st | 10 | PIT 25 | Diontae Johnson 6 yard Rushing Attempt Fred Warner | 6-3 | 0.6 |
| SF | 2nd | 0:50 | 1st | 10 | SF 20 | Dante Pettis -5 yard Passing Completion from Jimmy Garoppolo Joe Haden | 6-3 | -0.25 |
| PIT | 2nd | 1:56 | 2nd | 10 | SF 42 | Diontae Johnson 6 yard Passing Completion from Mason Rudolph Kwon Alexander | 6-3 | 0.6 |
| PIT | 2nd | 2:00 | 1st | 10 | SF 42 | Mason Rudolph Incomplete Pass to JuJu Smith-Schuster Richard Sherman | 6-3 | |
| PIT | 2nd | 3:46 | 1st | 10 | PIT 46 | Benny Snell 4 yard Rushing Attempt DeForest Buckner | 6-3 | 0.4 |
| PIT | 2nd | 4:53 | 1st | 10 | PIT 35 | James Conner 2 yard Rushing Attempt D.J. Jones | 6-3 | 0.2 |
| PIT | 2nd | 6:45 | 1st | 10 | PIT 25 | James Conner -2 yard Rushing Attempt Kwon Alexander | 6-3 | -0.2 |
| SF | 2nd | 9:35 | 1st | 10 | PIT 26 | Matt Breida 4 yard Rushing Attempt Stephon Tuitt | 6-0 | 0.4 |
| SF | 2nd | 10:37 | 1st | 10 | PIT 49 | Dante Pettis 8 yard Passing Completion from Jimmy Garoppolo Minkah Fitzpatrick | 6-0 | 0.8 |
| PIT | 2nd | 11:17 | 3rd | 10 | PIT 7 | Mason Rudolph 1 yard Rushing Attempt Ronald Blair | 6-0 | 0.1 |
| PIT | 2nd | 11:20 | 2nd | 10 | PIT 7 | Mason Rudolph Incomplete Pass to Xavier Grimble | 6-0 | |
| PIT | 2nd | 11:25 | 1st | 10 | PIT 7 | Mason Rudolph Incomplete Pass to James Washington | 6-0 | |
| SF | 2nd | 12:29 | 1st | 10 | PIT 40 | Marquise Goodwin 16 yard Passing Completion from Jimmy Garoppolo Joe Haden | 6-0 | 1.6 |
| SF | 2nd | 13:06 | 1st | 10 | SF 38 | Kyle Juszczyk 22 yard Passing Completion from Jimmy Garoppolo Terrell Edmunds | 6-0 | 2.2 |
| PIT | 2nd | 14:12 | 1st | 10 | PIT 19 | James Conner 5 yard Rushing Attempt Jaquiski Tartt | 6-0 | 0.5 |
| PIT | 2nd | 14:51 | 1st | 10 | PIT 9 | Vance McDonald 10 yard Passing Completion from Mason Rudolph Solomon Thomas | 6-0 | 1 |
| SF | 1st | 0:44 | 1st | 10 | PIT 28 | Raheem Mostert 3 yard Rushing Attempt T.J. Watt | 6-0 | 0.3 |
| SF | 1st | 0:55 | 1st | 10 | SF 45 | Kyle Juszczyk 27 yard Passing Completion from Jimmy Garoppolo Terrell Edmunds | 6-0 | 2.7 |
| SF | 1st | 1:59 | 1st | 10 | SF 31 | Raheem Mostert 2 yard Rushing Attempt Mike Hilton | 6-0 | 0.2 |
| PIT | 1st | 3:31 | 2nd | 10 | SF 13 | James Conner 4 yard Passing Completion from Mason Rudolph DeForest Buckner | 3-0 | 0.4 |
| PIT | 1st | 3:34 | 1st | 10 | SF 13 | Mason Rudolph Incomplete Pass to JuJu Smith-Schuster | 3-0 | |
| PIT | 1st | 4:44 | 1st | 10 | SF 24 | James Washington 8 yard Passing Completion from Mason Rudolph Tarvarius Moore | 3-0 | 0.8 |
| SF | 1st | 5:28 | 1st | 10 | SF 28 | Matt Breida -1 yard Rushing Attempt Cameron Heyward | 3-0 | -0.1 |
| PIT | 1st | 6:54 | 1st | 10 | PIT 20 | James Conner 5 yard Rushing Attempt DeForest Buckner | 3-0 | 0.5 |
| SF | 1st | 9:04 | 1st | 10 | SF 49 | Jimmy Garoppolo Rushing Attempt Fumble recovered by Raheem Mostert Bud Dupree | 3-0 | -1 |
| PIT | 1st | 10:48 | 1st | 10 | PIT 37 | -9 yard Sack Stephon Tuitt | 3-0 | 2 |
| SF | 1st | 11:40 | 1st | 10 | SF 25 | Matt Breida 4 yard Rushing Attempt Javon Hargrave | 3-0 | 0.4 |
| PIT | 1st | 13:09 | 2nd | 10 | SF 33 | JuJu Smith-Schuster -2 yard Passing Completion from Mason Rudolph Ahkello Witherspoon | 0-0 | -0.1 |
| PIT | 1st | 13:47 | 1st | 10 | SF 33 | James Conner Passing Completion from Mason Rudolph Kwon Alexander | 0-0 | |
| PIT | 1st | 13:54 | 1st | 10 | PIT 42 | Jimmy Garoppolo Pass to Matt Breida Interception by T.J. Watt Mike Person | 0-0 | 2 |
| SF | 1st | 15:00 | 1st | 10 | SF 25 | Matt Breida 5 yard Rushing Attempt Devin Bush | 0-0 | 0.5 |
| SF | 4th | 2:00 | 1st | Goal | PIT 9 | Jeff Wilson 4 yard Rushing Attempt Javon Hargrave | 20-17 | 0.4 |
| PIT | 3rd | 6:37 | 2nd | 9 | PIT 19 | James Conner 5 yard Passing Completion from Mason Rudolph DeForest Buckner | 6-10 | 0.5 |
| SF | 2nd | 10:48 | 4th | 9 | SF 8 | Richie James 14 yard Punt Return Attempt Jayrone Elliott | 6-0 | |
| SF | 4th | 7:44 | 1st | Goal | PIT 8 | Jeff Wilson 1 yard Rushing Attempt Javon Hargrave | 20-17 | 0.1 |
| SF | 3rd | 1:39 | 2nd | 8 | PIT 16 | Dante Pettis 12 yard Passing Completion from Jimmy Garoppolo Devin Bush | 13-10 | 1.2 |
| SF | 3rd | 11:23 | 3rd | 8 | PIT 25 | Kendrick Bourne 22 yard Passing Completion from Jimmy Garoppolo Joe Haden | 6-3 | 2.2 |
| SF | 3rd | 11:26 | 2nd | 8 | PIT 25 | Jimmy Garoppolo Incomplete Pass to Raheem Mostert Bud Dupree | 6-3 | |
| PIT | 2nd | 4:17 | 2nd | 8 | PIT 37 | Johnny Holton 9 yard Rushing Attempt Richard Sherman | 6-3 | 0.9 |
| SF | 1st | 1:17 | 2nd | 8 | SF 33 | George Kittle 12 yard Passing Completion from Jimmy Garoppolo Terrell Edmunds | 6-0 | 1.2 |
| SF | 4th | 6:53 | 3rd | Goal | PIT 7 | Jimmy Garoppolo Rushing Attempt Richie James Fumble Lost recovered by T.J. Watt Richie James | 20-17 | 1 |
| SF | 4th | 7:00 | 2nd | Goal | PIT 7 | Jimmy Garoppolo Incomplete Pass | 20-17 | |
| PIT | 4th | 15:00 | 3rd | 7 | PIT 28 | James Washington 6 yard Passing Completion from Mason Rudolph Richard Sherman | 13-17 | 0.6 |
| PIT | 2nd | 5:24 | 3rd | 7 | PIT 28 | Diontae Johnson 7 yard Passing Completion from Mason Rudolph Jaquiski Tartt | 6-3 | 0.7 |
| SF | 2nd | 11:29 | 2nd | Goal | PIT 7 | Jimmy Garoppolo Rushing Attempt Fumble Lost recovered by Devin Bush Mike Person | 6-0 | 1 |
| SF | 2nd | 11:34 | 1st | Goal | PIT 7 | Jimmy Garoppolo Incomplete Pass to George Kittle | 6-0 | |
| SF | 2nd | 15:00 | 2nd | 7 | PIT 25 | Raheem Mostert Rushing Attempt Fumble Lost recovered by Devin Bush Minkah Fitzpatrick | 6-0 | 1 |
| PIT | 2nd | 3:14 | 2nd | 6 | Midfield | Benny Snell 2 yard Rushing Attempt D.J. Jones | 6-3 | 0.2 |
| SF | 2nd | 9:11 | 3rd | 6 | PIT 22 | George Kittle 11 yard Passing Completion from Jimmy Garoppolo Minkah Fitzpatrick | 6-0 | 1.1 |
| SF | 2nd | 9:15 | 2nd | 6 | PIT 22 | Jimmy Garoppolo Incomplete Pass to George Kittle T.J. Watt | 6-0 | |
| PIT | 1st | 2:47 | 3rd | 6 | SF 9 | Mason Rudolph 1 yard Rushing Attempt DeForest Buckner | 3-0 | 0.1 |
| SF | 1st | 11:11 | 2nd | 6 | SF 29 | Matt Breida 8 yard Rushing Attempt Cameron Heyward | 3-0 | 0.8 |
| SF | 4th | 1:20 | 2nd | Goal | PIT 5 | Dante Pettis 5 yard Passing TD from Jimmy Garoppolo | 20-23 | 6.5 |
| PIT | 4th | 6:11 | 2nd | 5 | PIT 19 | James Conner 5 yard Passing Completion from Mason Rudolph Kwon Alexander | 20-17 | 0.5 |
| SF | 4th | 9:21 | 2nd | 5 | PIT 38 | Raheem Mostert 19 yard Rushing Attempt Steven Nelson | 20-17 | 1.9 |
| SF | 3rd | 3:10 | 2nd | 5 | PIT 39 | Matt Breida 10 yard Rushing Attempt Terrell Edmunds | 13-10 | 1 |
| SF | 3rd | 7:23 | 3rd | 5 | SF 30 | Jimmy Garoppolo Incomplete Pass to Kendrick Bourne | 6-10 | |
| SF | 3rd | 8:22 | 4th | 5 | SF 27 | Richie James 11 yard Punt Return Attempt Ola Adeniyi | 6-10 | |
| PIT | 3rd | 8:26 | 3rd | 5 | PIT 27 | Mason Rudolph Incomplete Pass to JuJu Smith-Schuster | 6-10 | |
| SF | 3rd | 12:41 | 2nd | 5 | PIT 33 | Matt Breida 6 yard Rushing Attempt T.J. Watt | 6-3 | 0.6 |
| SF | 2nd | 6:48 | 4th | 5 | PIT 6 | Robbie Gould 24 yard Field Goal Made | 6-3 | 3 |
| SF | 2nd | 13:21 | 4th | 5 | SF 24 | Richie James 15 yard Punt Return Attempt Artie Burns | 6-0 | |
| PIT | 2nd | 13:25 | 3rd | 5 | PIT 24 | Mason Rudolph Incomplete Pass to Diontae Johnson | 6-0 | |
| PIT | 2nd | 13:30 | 2nd | 5 | PIT 24 | Mason Rudolph Incomplete Pass to Vance McDonald | 6-0 | |
| PIT | 1st | 2:07 | 4th | 5 | SF 8 | Chris Boswell 26 yard Field Goal Made | 6-0 | 3 |
| SF | 1st | 5:40 | 4th | 5 | SF 25 | Richie James 8 yard Punt Return Attempt Benny Snell | 3-0 | |
| PIT | 1st | 5:43 | 3rd | 5 | PIT 25 | Mason Rudolph Incomplete Pass to Diontae Johnson | 3-0 | |
| PIT | 1st | 6:20 | 2nd | 5 | PIT 25 | James Conner Rushing Attempt D.J. Jones | 3-0 | |
| PIT | 1st | 11:52 | 4th | 5 | SF 28 | Chris Boswell 46 yard Field Goal Made | 3-0 | 4 |
| SF | 1st | 14:29 | 2nd | 5 | SF 30 | George Kittle 12 yard Passing Completion from Jimmy Garoppolo Terrell Edmunds | 0-0 | 1.2 |
| SF | 4th | 8:11 | 2nd | 4 | PIT 13 | Jeff Wilson 5 yard Rushing Attempt Tyson Alualu | 20-17 | 0.5 |
| SF | 3rd | 1:02 | 1st | Goal | PIT 4 | Jeff Wilson 4 yard Rushing TD | 13-16 | 6.4 |
| PIT | 3rd | 5:54 | 3rd | 4 | PIT 24 | JuJu Smith-Schuster 76 yard Passing TD from Mason Rudolph | 12-10 | 15.6 |
| PIT | 3rd | 14:31 | 2nd | 4 | PIT 31 | James Conner 6 yard Rushing Attempt Fred Warner | 6-3 | 0.6 |
| SF | 2nd | 1:12 | 3rd | 4 | PIT 36 | -5 yard Sack Dee Ford | 6-3 | 2 |
| PIT | 2nd | 2:35 | 3rd | 4 | SF 48 | Mason Rudolph 6 yard Rushing Attempt Ahkello Witherspoon | 6-3 | 0.6 |
| PIT | 4th | 0:51 | 3rd | 3 | PIT 29 | Mason Rudolph -9 yard Sack DeForest Buckner Fumble recovered by Matt Feiler Nick Bosa | 20-24 | -2.35 |
| SF | 4th | 10:08 | 2nd | 3 | SF 32 | Marquise Goodwin 25 yard Passing Completion from Jimmy Garoppolo Terrell Edmunds | 20-17 | 2.5 |
| SF | 3rd | 10:01 | 2nd | Goal | PIT 3 | Kyle Juszczyk 2 yard Passing Completion from Jimmy Garoppolo Stephon Tuitt | 6-3 | 0.2 |
| SF | 3rd | 10:43 | 1st | Goal | PIT 3 | Jeff Wilson Rushing Attempt Stephon Tuitt | 6-3 | |
| SF | 2nd | 9:59 | 2nd | 2 | PIT 41 | Matt Breida 15 yard Passing Completion from Jimmy Garoppolo Joe Haden | 6-0 | 1.5 |
| PIT | 1st | 4:17 | 2nd | 2 | SF 16 | James Conner 3 yard Rushing Attempt Dre Greenlaw | 3-0 | 0.3 |
| SF | 4th | 4:13 | 3rd | 1 | PIT 15 | Jimmy Garoppolo 2 yard Rushing Attempt Javon Hargrave | 20-17 | 0.2 |
| SF | 4th | 4:49 | 2nd | 1 | PIT 15 | Jeff Wilson Rushing Attempt Stephon Tuitt | 20-17 | |
| SF | 4th | 14:13 | 4th | 1 | SF 34 | Richie James 5 yard Punt Return Attempt Jayrone Elliott | 13-17 | |
| SF | 3rd | 4:54 | 3rd | 1 | SF 34 | Jimmy Garoppolo 2 yard Rushing Attempt Cameron Heyward | 13-10 | 0.2 |
| SF | 3rd | 5:15 | 2nd | 1 | SF 34 | Raheem Mostert Rushing Attempt Bud Dupree | 13-10 | |
| SF | 3rd | 9:21 | 3rd | Goal | PIT 1 | Jeff Wilson 1 yard Rushing TD | 6-9 | 6.1 |
| PIT | 4th | 1:15 | | | PIT 35 | Johnny Holton 21 yard Kick Return Attempt D.J. Reed | 20-24 | |
| SF | 4th | 1:15 | | | PIT 15 | Robbie Gould XP | 20-24 | 1 |
| PIT | 4th | 10:22 | | | SF 15 | Chris Boswell XP | 20-17 | 1 |
| SF | 3rd | 0:56 | | | PIT 15 | Robbie Gould XP | 13-17 | 1 |
| PIT | 3rd | 5:42 | | | SF 15 | Chris Boswell XP | 13-10 | 1 |
| PIT | 3rd | 9:17 | | | PIT 35 | Johnny Holton 21 yard Kick Return Attempt Azeez Al-Shaair | 6-10 | |
| SF | 3rd | 9:17 | | | PIT 15 | Robbie Gould XP | 6-10 | 1 |
| SF | 1st | 2:04 | | | SF 35 | Richie James 22 yard Kick Return Attempt Jordan Dangerfield | 6-0 | |
| SF | 1st | 11:47 | | | SF 35 | Richie James 26 yard Kick Return Attempt Tyler Matakevich | 3-0 | |