Coach Sean McDermott said Moss (toe) was ruled out for Sunday's game against the Rams, Chris Brown of the Bills' official site reports.

EDGE Analysis

The rookie third-rounder was unable to practice Wednesday and Thursday, and it appears his outlook hasn't improved much entering Friday's session. Moss carried 17 times for 48 yards and caught three passes for 16 yards and one touchdown in the first two games of the season, but he won't be available for Week 3. Devin Singletary played just under 60 percent of the offensive snaps the past two weeks but is now likely to have a larger snap share versus the Rams.

Moss (toe) isn't on the field for Thursday's practice, Chris Brown of the Bills' official site reports.

EDGE Analysis

He'll go down as a non-participant for the second day in a row, leaving his status uncertain for Sunday's game against the Rams. Before determining whether he'll carry a designation into the Week 3 contest, the Bills will see what Moss can do during their final practice session Friday. If Moss ends up missing the first game of his career, starting running back Devin Singletary -- who hasn't played more than 60 percent of the offensive snaps in either of the Bills' first two contests -- will likely be headed for a bigger workload.

Moss didn't practice Wednesday due to a toe injury.

EDGE Analysis

Keep an eye on Moss's practice participation as the week unfolds, as he'll likely need to graduate to at least limited activity by Friday to have a shot at avoiding an injury designation heading into Sunday. If Moss is limited or out Week 3 against the Rams, Devin Singletary would be in line for an increased share of the backfield reps.

Moss rushed eight times for 37 yards and wasn't targeted in the passing game in the Bills' 31-28 win over the Dolphins on Sunday.

EDGE Analysis

With the contest turning out to be very competitive courtesy of a see-saw fourth quarter, the Bills tilted more toward the passing game than usual with considerable success. In turn, that left Moss and backfield mate Devin Singletary with a relatively modest workload, and the former trailed the latter by two rushing touches by afternoon's end. Moss disappointingly was a complete non-factor through the air as well after seeing four targets in his Week 1 pro debut, leaving fantasy managers to hope for more well-rounded production in a Week 3 interconference home tilt against the Rams next Sunday.

Moss rushed nine times for 11 yards and caught three of four targets for 16 yards and a touchdown in Sunday's 27-17 win over the Jets.

EDGE Analysis

Moss split the rushing work evenly with Devin Singletary (nine carries for 30 yards), but it was quarterback Josh Allen who paced Buffalo's ground game with 14 carries for 57 yards and a touchdown. Allen's power-running style will likely rob Moss of some short touchdowns, but the rookie was on the field when the Bills got in close and caught a four-yard touchdown in the second quarter. Neither running back was able to separate himself in this one, so expect Moss and Singletary to see a near-even split in touches against the Dolphins in Week 2.

It isn't clear how the Bills will split playing time between Moss and Devin Singletary, but it does seem that Moss is more likely to get goal-line touches, according to Joe Buscaglia of The Athletic.

EDGE Analysis

The report kind of hints at a traditional thunder/lightning backfield split, though Singletary wins with agility and vision more so than speed, while Moss is surprisingly nimble in the passing game for a 5-foot-9, 223-pound running back. In other words, both players appear reasonably versatile, which makes it tougher to get a read on the exact nature of their respective roles. It still isn't clear if Singletary's lead role from late last season will carry over to Week 1 against the Jets, as it's also possible Moss forces something closer to a 50/50 split right out of the gate. The Buffalo backfield will be one of the major fantasy storylines for the opening week of the season.

Moss (neck) isn't wearing a no-contact jersey Tuesday, Marcel Louis-Jacques of ESPN.com reports.

EDGE Analysis

It appears the rookie's neck injury was minor, as he's been cleared for contact work after only a few days of being limited. Devin Singletary remains the favorite to start in the backfield Week 1 against the Jets, but Moss also figures to have a significant role in the Buffalo offense.

Moss was listed as a non-contact participant Sunday due to a neck issue, Sal Capaccio of WGR Sports Radio 550 Buffalo reports.

EDGE Analysis

Moss's injury at first glance appears more minor than some of the other injured Bills, as they were all listed as missing practice while Moss was the only non-contact participant. We'll see if he can shake that label in the coming days as he continues to work toward a chunk of playing time to open the season in tandem with Devin Singletary.

Moss has displayed his ability as a pass-catcher in practice of late, Maddy Glab of the Bills' official site reports.

EDGE Analysis

It's already established that Moss, a tackle-breaking runner, could end up being in the mix to see work on short-yardage plays as a rookie, but if he continues to show receiving aptitude it can only help his chances of see added touches behind presumed starter Devin Singletary.

Moss has signed his four-year rookie contract.

EDGE Analysis

That puts to bed the contracts of all seven Bills rookies from the 2020 draft class. As for Moss, he's certainly an intriguing rookie based on his power and production at Utah. Devin Singletary is the starter, but he's a smaller back and it should be pretty easy for Moss to eke out a meaningful role right away. The quickest path to first-year fantasy value -- barring an injury to Singletary -- would be for Moss to assert himself as the clear guy for tougher carries in short-yardage and goal-line situations.