The Bills placed Palmer (ankle) on injured reserve Saturday.

EDGE Analysis

Palmer was held out of all drills Wednesday through Friday due to an ankle injury before Buffalo ruled him out for Sunday's wild-card game at Jacksonville. Considering he's required to miss at least four contests while on IR, his 2025 campaign is over. Palmer will finish it with a 22-303-0 line on 37 targets in 12 regular-season appearances.

Palmer (ankle) has been ruled out for Sunday's AFC wild-card game against the Jaguars.

EDGE Analysis

Palmer was held out of practice all week due to an ankle injury, which is severe enough for the veteran wideout to be sidelined for the Bills' playoff opener. With Palmer sidelined, Cameron Wolfe of NFL Network reports that Keon Coleman -- who was a healthy inactive in four of the Bills' final eight games of the regular season -- is expected to be active against Jacksonville. Brandin Cooks and Tyrell Shavers are also in line for more snaps on offense in Palmer's absence.

Palmer (ankle) won't practice Friday and will be listed as questionable for Sunday's playoff opener against the Jaguars, Alaina Getzenberg of ESPN.com reports.

EDGE Analysis

Palmer thus will finish the week with three consecutive 'DNPs,' which clouds the wideout's status for Sunday's 1:00 p.m. ET kickoff. In 12 contests during the regular season, Palmer put up a 22-303-0 line on 37 targets, a rate of production that limited his fantasy lineup viability to deeper formats.

Palmer (ankle) wasn't spotted at Thursday's practice, Alaina Getzenberg of ESPN.com reports.

EDGE Analysis

With Palmer having been deemed a 'DNP' in Wednesday's walkthrough, the wideout now has one more opportunity to practice before the Bills assign injury designations for Sunday's playoff opener against the Jaguars. Palmer recorded an 84 percent snap share in the team's Week 18 win over the Jets, but at this stage it's unclear if the wideout is dealing with a setback related to the ankle injury that he previously dealt with in Weeks 13-15, or if his current issue is something new.

Palmer (ankle) was listed as a non-participant in Wednesday's walk-through practice.

EDGE Analysis

Palmer missed Weeks 13 and 14 with an ankle injury, but up until Wednesday he'd been a full practice participant ever since returning to action Week 15. It's possible this is a new issue, and there's no assurance of a significant role in the playoffs even if Palmer's injury turns out to be minor. Buffalo's depth chart has been fluid apart from Khalil Shakir's role in the slot, but Brandin Cooks and Tyrell Shavers have contributed more than Palmer of late. Gabe Davis and Keon Coleman are the other candidates for WR snaps this Sunday at Jacksonville.

Palmer caught one pass (on three targets) for one yard during the Bills' 35-8 win over the Jets on Sunday.

EDGE Analysis

Palmer played a season-high 63 snaps on offense during Sunday's win, but he had just one catch to show for it. The 2025 season looked promising for the fifth-year wideout after posting five catches (on nine targets) for 61 yards during the Bills' Week 1 win over the Ravens, but those numbers ended up being season highs for Palmer. The Bills hit the road for their AFC wild-card game against the Jaguars this Sunday, when Palmer figures to be a depth option in the passing game behind Khalil Shakir, Brandin Cooks, James Cook and Dalton Kincaid.

Palmer caught one of two targets for 12 yards in Sunday's 13-12 loss to the Eagles.

EDGE Analysis

Palmer has exactly one catch in three straight games, totaling 30 scoreless yards. He's way off the fantasy map headed into Week 18 against the Jets and figures to continue playing rotational snaps in Buffalo's hodgepodge receiver corps during the postseason.

Palmer caught his lone target for two yards in Sunday's 23-20 win over the Browns.

EDGE Analysis

Since returning from injury in the Bills' Week 15 win over the Patriots, Palmer has caught two of three targets for just 18 yards. However, he's played the third-most offensive snaps (58) amongst Buffalo wideouts during that span, trailing Khalil Shakir (72) and Tyrell Shavers (64). Palmer likely won't carry much fantasy value in the Week 17 matchup against the Eagles, despite playing as one of the Bills' top wide receivers.

Palmer caught one of two targets for 16 yards in Sunday's 35-31 win over the Patriots.

EDGE Analysis

Palmer was held to one catch for the first time since Week 3, though he's yet to exceed two receptions in a contest since Week 1. The wide receiver finished fourth on the team in receiving yards, while his two targets were his fewest since returning from an ankle injury in Week 11. Palmer will look to be more involved in the team's matchup with the Browns on Dec. 21.

Palmer (ankle) is listed as active for Sunday's game against the Patriots.

EDGE Analysis

Palmer, who has missed the Bills' last two games, was limited in practice this week before approaching the contest listed as questionable. In his return to action Sunday, he'll rejoin a wideout corps that also includes Khalil Shakir, Keon Coleman, Tyrell Shavers and Brandin Cooks. In Buffalo's Week 14 win over the Bengals, the team's TEs were targeted a combined 13 times, while none of the WRs saw more than three targets. Prior to his injury, Palmer caught two passes in each of his previous five contests, a rate of production that limits his fantasy lineup viability to deeper formats.