Adams (thumb) has been ruled out ahead of Sunday's matchup against the 49ers, Josh Weinfuss of ESPN.com reports.

EDGE Analysis

Adams was unable to practice all week after he seemingly sustained a thumb injury during the Cardinals' Week 4 loss to the Commanders, so it's no surprise he won't suit up Sunday. Expect Trystan Colon to serve as Arizona's top reserve guard while Adams is sidelined in Week 5.