Aiyuk, who suffered a high-ankle sprain in this past Saturday's win over the Cardinals, won't play in Sunday's season finale against the Seahawks, Nick Wagoner of ESPN.com reports.

EDGE Analysis

Aiyuk thus finishes the campaign with a team-high 60 catches (on 96 targets) for 748 yards and five TDs in 12 games. Looking ahead to next season, the 2020 first-rounder will bring solid fantasy upside to the table, but the 49ers offense could look a bit different next season, once the team's offseason personnel moves shake out.