Fisher (knee) will not return Saturday against the Cardinals, Zak Keefer of The Athletic reports.

EDGE Analysis

Fisher's inability to return will put severe pressure on the Colts' offensive line depth, which was already missing three starters. Ryan Kelly due to personal reasons, and Quenton Nelson and Mark Glowisnki due to being on the COVID list. In Fisher's absence, Julie'n Davenport will likely step in.