Bledsoe (calf) has been ruled out of Sunday's matchup against the Bills, Mike Reiss of ESPN.com reports.

EDGE Analysis

Bledsoe has missed the entire season due to a wrist injury that he suffered at the Senior Bowl. While it appeared that he would be ready to make his professional debut, Bledsoe is now plagued by a calf injury. He logged full practices to begin the week, so it's likely that he picked up the issue during one of those sessions.