Head coach Kyle Shanahan said Mitchell (knee) won't practice Wednesday, Nick Wagoner of ESPN.com reports.

EDGE Analysis

Mitchell has missed the last two games due to a knee injury, and his inability to practice to kick off Week 6 prep could mean another absence is on the horizon this Sunday in Cleveland. As long as Mitchell is sidelined, Jordan Mason will be next in line to absorb any snaps and touches that don't go to the 49ers' top running back, Christian McCaffrey.