Mattison will be the Vikings' lead running back Sunday versus the Lions with Dalvin Cook (ankle) inactive, Courtney Cronin of ESPN.com reports.

EDGE Analysis

This will mark Mattison's second spot start of the campaign in place of Cook. In Week 3, Mattison was a workhorse against the Seahawks, turning 26 carries into 112 yards and six catches (on eight targets) into 59 yards. He has a good matchup on tap in which to produce this time around, too, as Detroit's defense has given up 134.8 yards from scrimmage per game and nine total TDs to running backs in four contests this season.