49ers coach Kyle Shanahan said Monday that Guerendo (shoulder) is expected to miss a couple weeks, Matt Maiocco of NBC Sports Bay Area reports.

EDGE Analysis

Guerendo made an early exit from Saturday's practice and apparently won't be back for a while. It sounds like he has a chance to be ready for Week 1, but a preseason appearance probably isn't in the cards. Guerendo's absence could give rookie Jordan James more opportunities to mix in with the first-team offense, especially on days when Christian McCaffrey is rested.