Taylor (ankle) won't practice Wednesday, James Boyd of The Athletic reports.

EDGE Analysis

Taylor, who missed this past Sunday's 37-34 loss to the Jaguars, has two more chances to return to practice ahead of this weekend's game against the Titans. If the running back is forced to miss a second straight game, Trey Sermon and Tyler Goodson would be in line to share backfield duties for the Colts in Week 6.