The Cardinals placed Williams (knee) on injured reserve Wednesday, Darren Urban of the team's official site reports.

EDGE Analysis

The 2015 second-round pick was threatening for a Year 7 breakout before he suffered a major knee injury in the Week 5 win over San Francisco. While the Cardinals haven't confirmed that it's a season-ending injury, multiple reports suggest Williams likely tore a ligament. Prior to Sunday, he enjoyed the most productive stretch of his career in Weeks 2 through 4, catching 15 of 15 targets for 179 yards and a touchdown. The Cardinals are now left with Darrell Daniels, Demetrius Harris and recent practice-squad signing Richard Rodgers at tight end.