Jacobs (ankle) didn't practice Wednesday, Paul Gutierrez of ESPN.com reports.

EDGE Analysis

Coach Jon Gruden was pessimistic Monday about Jacobs' chances of suiting up Sunday against the Colts, and not much seems to have changed two days later. If Jacobs is forced to miss a second consecutive game, Devontae Booker would be in line to headline Vegas' backfield again, with Jalen Richard and Theo Riddick also on hand.