The 49ers designated Sanu (knee) for return from injured reserve Wednesday.

EDGE Analysis

Sanu has missed eight games in a row due to a sprained knee sustained Week 9 against the Cardinals. With his practice window now open, he'll have a trio of chances this week to prove his health ahead of Sunday's season finale at the Rams. Even if he's activated for Week 18, Sanu would be competing with Jauan Jennings and Trent Sherfield for snaps and targets behind the 49ers' top two wide receivers Deebo Samuel and Brandon Aiyuk.