Jefferson left Sunday's game against the 49ers due to a leg injury, Adam Schefter of ESPN reports.

EDGE Analysis

Jefferson remained on the turf for a spell before making his way to the sideline tent near the end of the third quarter. He then went to the locker room. Prior to his exit, Jefferson recorded four catches (on seven targets) for 133 yards and one touchdown, a line fueled by a 97-yard score.