An MRI confirmed that Downs suffered a left high-ankle sprain during Wednesday's practice, Joel A. Erickson of The Indianapolis Star reports.

EDGE Analysis

Per Ian Rapoport of NFL Network, Downs' recovery time could fall in the 4-to-6-week range, though the Colts are hopeful that the wideout will be ready to go around the shorter end of the estimate. In any case, Downs' status for the Colts' Sept. 8 regular-season opener against the Texans could be affected. if so, added opportunities would be available early on for fellow wideouts Adonai Mitchell and Alec Pierce behind No. 1 receiver Michael Pittman.