Brandon Jacobs (knee) has been ruled out for Week 6 against Buffalo. Jacobs will miss a second straight game with an incredibly swollen knee. Giants S Antrel Rolle described it as "volleyball" sized earlier in the week. Jacobs will try to use the Week 7 bye to manage the swelling and get back on the practice field before Week 8. Ahmad Bradshaw may flirt with 30 touches against the Bills' weak run defense, which may be minus NT Kyle Williams (ankle).