49ers NT Isaac Sopoaga (staph infection) was spotted with his left arm in a sling at the team facility Monday morning. The Niners have yet to expand on details about Sopoaga's condition, other than to confirm that he has an infection and is out indefinitely. Ricky Jean-Francois started for Sopoaga in Sunday's demolition of the Buccaneers. Jean-Francois played every single snap, recording three tackles (two solo).

49ers NT Isaac Sopoaga (staph infection) is inactive for Sunday's game against the Bucs. Undersized NT Ricky Jean-Francois will start and LaGarrette Blount gets a bump for the favorable matchup. QB Scott Tozien, FB Moran Norris, WR Braylon Edwards, OL Michael Person, OL Daniel Kilgore, and CB Tramaine Brock join him on the inactive list.

49ers NT Isaac Sopoaga has been diagnosed with a staph infection and is out indefinitely. The area of the staph infection is unknown, but Sopoaga was held out of practice Wednesday. His absence could be a bit of a matchup boost for LeGarrette Blount in Week 5. Undersized Ricky Jean-Francois is Sopoaga's backup.

The 49ers are expected to move Isaac Sopoaga to nose tackle full time this season, replacing Aubrayo Franklin. The Niners just aren't going to pay Franklin. Sopoaga, the team's starting left end for the past three seasons, certainly looks the part of a nose at 6-foot-2, 330. Pro Football Focus has graded Sopoaga as a poor run defender in each of those years, however. We expect San Francisco to be at least a slightly easier fantasy matchup for opposing running backs this season.