Manzardo was scratched from Friday's Cactus League lineup due to left shoulder inflammation, SI.com reports.

EDGE Analysis

The severity of the injury is unclear, but Manzardo will be withheld from the lineup for at least one game. The 24-year-old will have a few opportunities to play in exhibition games ahead of Opening Day in Kansas City on Thursday.

Manzardo went 1-for-5 with a two-run home run in Saturday's spring game against the Royals.

EDGE Analysis

Manzardo launched his third Cactus League home run and is batting .412 (14-for-34) with five extra-base hits and seven RBI through 13 games. The 24-year-old should be a lineup regular in 2025 for the Guardians, either at designated hitter or first base.

Manzardo started at designated hitter and went 1-for-2 with a two-run home run in Monday's spring game against the Diamondbacks.

EDGE Analysis

Manzardo connected on a changeup for his first home run of the Cactus League. The 24-year-old got his feet wet in the majors last season and is viewed as a potential replacement for the power lost when the Guardians sent Josh Naylor to Arizona during the offseason. The left-handed batter fared well against all pitching in the minors but was held to a .566 OPS and just 19 at-bats against southpaws in the majors.

Manzardo isn't in the lineup for Game 5 of the ALCS against the Yankees, Zack Meisel of The Athletic reports.

EDGE Analysis

With southpaw Carlos Rodon set to start on the bump for New York, the left-handed bat of Manzardo will stay put in the Guardians' dugout. David Fry will step in as the designated hitter and bat second.

Manzardo isn't in the starting lineup Saturday for Game 5 of the ALDS against the Tigers, Zack Meisel of The Athletic reports.

EDGE Analysis

With left-hander Tarik Skubal set to start the game for Detroit, the left-handed bat of Manzardo will step out of the starting nine Saturday. His absence will put David Fry in the DH spot, batting second.

Manzardo is not in the lineup Monday for Game 2 of the ALDS against the Tigers, Zack Meisel of The Athletic reports.

EDGE Analysis

It's lefty ace Tarik Skubal on the bump for the Tigers, so the left-handed hitting Manzardo will grab a seat. David Fry is in the designated hitter spot and batting second for the Guardians.

Manzardo went 1-for-3 with a solo home run, a walk and an additional run scored in Tuesday's 6-1 win over the Reds.

EDGE Analysis

Manzardo has gone 7-for-18 with three homers and four walks over his last eight games. In his last four starts, he's batted second after having previously been in the bottom half of the order regularly. The 24-year-old is up to five homers, 15 RBI, 11 runs scored and a .248/.299/.451 slash line through 50 major-league games this season.

Manzardo is not in Sunday's lineup against the Cardinals.

EDGE Analysis

The lefty-hitting designated hitter will head to the bench, even with righty Andre Pallante on the hill for St. Louis. Manzardo went 0-for-5 with a walk and two strikeouts in the first two games of the series. Jose Ramirez is starting at DH while Angel Martinez gets the nod at third base.

Manzardo went 3-for-3 with a solo home run in Thursday's 3-2 win over Minnesota.

EDGE Analysis

Manzardo opened the scoring in the bottom of the first inning with a solo shot off Simeon Woods Richardson. The 24-year-old Manzardo's swung the bat well since he was recalled on Sep. 1, going 15-for-42 (.357) with four homers in 16 games after batting just .207 with a .571 OPS across 30 contests in his first stint with the Guardians earlier this year.

Manzardo is out of the lineup for Wednesday's game against the Twins.

EDGE Analysis

Manzardo had served as the Guardians' designated hitter in both of the team's last two matchups with righties, but he'll head to the bench Wednesday even though Minnesota is sending right-hander Bailey Ober to the hill. David Fry will fill in for Manzardo at DH and will bat fifth.