Wainwright will face the Cubs at Wrigley Field on Opening Day, MLB.com's Jennifer Langosch reports. Opening Day for the Cardinals will actually be April 5, as they're scheduled to face Jon Lester and the Cubs in the first game of the 2015 MLB season. There was never any doubt Wainwright would get the nod, as there haven't been any reports of issues with his abdomen since mid-March.