Santana (hamstring) will begin a rehab assignment Wednesday at High-A Fort Myers, Rhett Bollinger of MLB.com reports.

EDGE Analysis

Santana has avoided any setbacks since he progressed to running in the recent past, and thus, the Twins have given clearance to kick off the final stages of his recovery. Upon his eventual return to the majors, he'll be relegated to a deep reserve role, though Trevor Plouffe's rib injury could open the door for a bit more time at shortstop.