O'Neill is out of the lineup for Wednesday's game against the Astros, Gabrielle Starr of the Boston Herald reports.

EDGE Analysis

After making his return to the Red Sox on Saturday following a two-week absence due to a lower leg infection, O'Neill started each of the past four games but went just 2-for-15 with two walks against eight strikeouts. O'Neill's spot in Boston's everyday lineup still appears to be secure, but he'll get a chance to regroup Wednesday while the Red Sox close out their series in Houston. Rob Refsnyder will replace O'Neill in left field and will bat fifth.