Jeremy Guthrie struggled in his first career start at Coors Field Wednesday, allowing six runs on nine hits, two walks and two home runs in just 3 1/3 innings of Colorado's 17-8 win over the Giants. Guthrie notched just one strikeout five days after turning in seven strong innings against the Astros. A flyball pitcher who has always allowed his fair share of home runs, Guthrie's adjustment to Coors Field could be long and slow. He'll get the Padres at home next Monday.