Gregerson will be unavailable out of the Astros' bullpen Wednesday, MLB.com's Brian McTaggart reports. Gregerson pitched three of the last four days and threw at least 20 pitches in each outing, so he will be given the day to rest. That will double as a mental break with Gregerson giving up two earned runs in two of his last three appearances. It's not certain who would get the ball if the Astros end up in a save situation Wednesday, but Chad Qualls seems like the best bet.