Santana is out of the lineup for Thursday's game against the Orioles.

EDGE Analysis

Santana will get a standard veteran rest day while the Guardians and Orioles close out their four-game series with a matinee contest. With Santana on the bench, Kyle Manzardo will cover first base, while Jose Ramirez gets a day out of the infield and serves as the Guardians' designated hitter.