Plouffe left Tuesday's game with an oblique strain, MLB.com's Rhett Bollinger reports.

EDGE Analysis

This is pretty bad news with a little over three weeks left in the season. It would not be surprising if we didn't see Plouffe back in action until 2017, given the nature of the injury. Look for a combination of Jorge Polanco, Miguel Sano and Eduardo Escobar to get starts at third base for the foreseeable future. Plouffe hit .256/.300/.408 with 11 home runs in 341 plate appearances and missed significant time with injuries at different points in the season.