| Player | | Opp | | Rank | | 2012 Stats | | Fantasy | | Pts in Last | | Availability |
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| Name | Pos | Team | | Week 16 | | Draft | Pos | | Summary | | Total | Avg | | 3 | 5 | | Action | Status |
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| Carson Palmer | QB | OAK | |  @KC237Yd1TD 167.8 W 16-13 | | 194 | 11 | | 4,018Yd23TD | | 3,687.1 | 245.8 | | 151.87↓ | 187.72 | | Locked | Starting QB | | Philip Rivers | QB | SD | | @DET299Yd1TD 251.1 L 10-38 | | 93 | 18 | | 3,606Yd26TD | | 3,380.3 | 211.3 | | 153.93↓ | 186.1 | | Locked | Starting QB | | Michael Turner | RB | ATL | | @NO 75Yd 101.2 L 16-45 | | 161 | 27 | | 931Yd11TD | | 1,566 | 97.9 | | 78.8 | 75.88 | | Locked | Starting RB | | Willis McGahee | RB | DEN | | @BUF 64Yd 85.6 L 14-40 | | 153 | 32 | | 952Yd4TD | | 1,412 | 141.2 | | 113.6 | 141.8 | | Locked | Starting RB | | Frank Gore | RB | SF | | @SEA96Yd1TD 166 W 19-17 | | 60 | 15 | | 1,446Yd10TD | | 2,107.2 | 131.7 | | 122.53 | 124.64 | | Locked | Starting RB/WR | | Ryan Mathews | RB | SD | | @DET74Yd 101.8 L 10-38 | | 29 | 30 | | 959Yd1TD | | 1,452 | 121 | | 94 | 106.36 | | Locked | Starting RB/WR | | Marques Colston | WR | NO | | ATL81Yd1TD 101.6 W 45-16 | | 54 | 24 | | 1,154Yd10TD | | 1,472.4 | 92 | | 113.33 | 98.04 | | Locked | Starting WR | | Mike Wallace | WR | PIT | | STL82Yd 81.2 W 27-0 | | 52 | 43 | | 843Yd8TD | | 1,106.6 | 73.8 | | 92.53 | 69.88 | | Locked | Starting WR | | Larry Fitzgerald | WR | ARI | | @CIN105Yd1TD 136 L 16-23 | | 36 | 48 | | 798Yd4TD | | 1,067.8 | 66.7 | | 61.53 | 46.32 | | Locked | Starting WR | | Aaron Hernandez | TE | NE | | MIA37Yd 46 W 27-24 | | 41 | 24 | | 488Yd5TD | | 671.8 | 67.2 | | 69.13 | 81.48 | | Locked | Starting TE | | Neil Rackers | K | HOU | | @IND 3/3FG1/1XP 86 L 16-19 | | | | | | | | | | | | | Locked | Starting K | | Pittsburgh Steelers | TM | PIT | | STL3Sack 225.3 W 27-0 | | 278 | 15 | | 10INT37Sack1TD | | 4,072.5 | 254.5 | | 252.33 | 242.32 | | Locked | Starting TM | | New York Jets | TM | NYJ | | NYG1INT2Sack 439.2 L 14-29 | | 364 | 19 | | 2TD11INT30Sack3TD | | 3,938.8 | 246.2 | | 231.77 | 219 | | Locked | Starting TM | | Jason McCourty | DB | TEN | | JAC 95 W 23-17 | | 464 | 17 | | 4INT | | 1,159 | 72.4 | | 95 | 89 | | Locked | Starting DB | | Antrel Rolle | DB | NYG | | @NYJ 107 W 29-14 | | 631 | 25 | | 2INT | | 1,110 | 69.4 | | 56.67 | 72 | | Locked | Starting DB | | Terrell Suggs | LB | BAL | | CLE 35 W 20-14 | | 353 | 141 | | 2Sack | | 240 | 30 | | 16.67↓ | 25 | | Locked | Starting DL | | Justin Smith | DL | SF | | @SEA 35 W 19-17 | | 349 | | | 3Sack | | | | | | | | Locked | Starting DL | | Charles Johnson | DL | CAR | | TB 10 W 48-16 | | 177 | | | 12.5Sack | | | | | | | | Locked | Starting DB/D... | | Nick Barnett | LB | BUF | | DEN 45 W 40-14 | | 479 | 35 | | 1.5Sack | | 1,126 | 70.4 | | 65 | 69.4 | | Locked | Starting LB | | Daryl Smith | LB | JAC | | @TEN 75 L 17-23 | | 509 | 204 | | | | 65 | 21.7 | | 21.67 | 21.67 | | Locked | Starting LB | | Chad Greenway | LB | MIN | | @WAS 135 W 33-26 | | 233 | 7 | | 1INT3Sack | | 1,621 | 101.3 | | 87.67 | 93.6 | | Locked | Starting DB/D... | | Benched |
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| Josh Freeman | QB | TB | | @CAR 274Yd2TD 290.2 L 16-48 | | 144 | 13 | | 4,065Yd27TD | | 3,539 | 221.2 | | 246.67 | 219.18 | | Locked | Benched | | Matt Moore | QB | MIA | | @NE294Yd3TD 227.7 L 24-27 | | 742 | 51 | | 131Yd1TD | | 129.7 | 64.8 | | 64.85 | 64.85 | | Locked | Benched | | Daniel Thomas | RB | MIA | | @NE 3Yd 9.2 L 24-27 | | 113 | 63 | | 481Yd4TD | | 760.6 | 63.4 | | 23.33↓ | 47 | | Locked | Benched | | Reggie Wayne | WR | IND | | HOU106Yd1TD 136.6 W 19-16 | | 77 | 14 | | 1,350Yd5TD | | 1,750 | 109.4 | | 57↓ | 67↓ | | Locked | Benched | | Victor Cruz | WR | NYG | | @NYJ164Yd1TD 186.4 W 29-14 | | 42 | 23 | | 1,092Yd10TD | | 1,480.2 | 92.5 | | 43.6↓ | 78.16 | | Locked | Benched | | Michael Crabtree | WR | SF | | @SEA85Yd 88 W 19-17 | | 55 | 30 | | 1,113Yd9TD | | 1,414 | 88.4 | | 148.8 | 138.36 | | Locked | Benched | | Jabar Gaffney | WR | WAS | | MIN77Yd1TD 94.2 L 26-33 | | 478 | 172 | | 68Yd | | 96.8 | 32.3 | | 32.27 | 32.27 | | Locked | Benched | | Seattle Seahawks | TM | SEA | | SF2Sack 299.6 L 17-19 | | 119 | 20 | | 1TD18INT36Sack5TD | | 3,910.9 | 244.4 | | 246.77 | 237.9 | | Locked | Benched | | Antoine Bethea | DB | IND | | HOU 112 W 19-16 | | 584 | 18 | | 2Sack | | 1,155 | 72.2 | | 81.67 | 76 | | Locked | Benched | | Pat Angerer | LB | IND | | HOU 75 W 19-16 | | 465 | 125 | | | | 302 | 30.2 | | 59 | 42.4 | | Locked | Benched | | Desmond Bishop | LB | GB | | CHI 145 W 35-21 | | 151 | | | | | | | | | | | Locked | Benched | | Injured Reserve |
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| Jamaal Charles | RB | KC | | OAK L 13-16 | | 10 | 4 | | 1,745Yd6TD | | 2,724.8 | 170.3 | | 170.73 | 190.32 | | Locked | Injured IR | | Matt Forte | RB | CHI | | @GB L 21-35 | | 25 | 14 | | 1,434Yd6TD | | 2,137.6 | 142.5 | | 168.73 | 164.8 | | Locked | Injured IR | | Fred Jackson | RB | BUF | | DEN W 40-14 | | 81 | 46 | | 654Yd4TD | | 1,048 | 104.8 | | 104.33 | 108.76 | | Locked | Injured IR |
| | Record | 10-4 | | Points | 20,906.28-19,543.01 | | Rank | 4 | | Owner | wesjordan89 | | Last Lineup Change | 6 Months | | Previous | L FISH | | Current | W  @Rocke... | | Roster | Illegal 1 QB 2-5 3 RB 2-7 4 WR 3-7 1 TE 1-3 0 K 1-3 0 TM 2-4 1 DB 2-6 0 DL 2-6 0 LB 2-6 3 IR 3 |
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