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| Player | | Opp | | Rank | | 2012 Stats | | Fantasy | | Pts in Last | | Availability |
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| Name | Pos | Team | Bye | | Week 1 | | Draft | Pos | | Summary | | Total | Avg | | 3 | 5 | | Action | Status |
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| Tom Brady | QB | NE | 10 | | @BUF 1:00 | | 7 | 3 | | 4,827Yd38TD | | 792.3 | 49.5 | | 48 | 47.68 | | Locked | Starting QB | | Frank Gore | RB | SF | 9 | | GB 4:25 | | 61 | 10 | | 1,446Yd10TD | | 232.6 | 14.5 | | 13.47 | 13.74 | | Locked | Starting RB | | Shonn Greene | RB | TEN | 8 | | @PIT 1:00 | | 127 | 19 | | 1,214Yd8TD | | 188.4 | 11.8 | | 13.53 | 12.94 | | Locked | Starting RB/W... | | Stevie Johnson | WR | BUF | 12 | | NE 1:00 | | 66 | 19 | | 1,046Yd6TD | | 223.6 | 14 | | 17 | 14.78 | | Locked | Starting WR | | Brandon Marshall | WR | CHI | 8 | | CIN 1:00 | | 18 | 2 | | 1,506Yd11TD | | 337.4 | 21.1 | | 15.07↓ | 20.74 | | Locked | Starting RB/W... | | Vernon Davis | TE | SF | 9 | | GB 4:25 | | 40 | 20 | | 548Yd5TD | | 125.8 | 7.9 | | 2.4↓ | 2.42↓ | | Locked | Starting TE | | Stephen Gostkowski | K | NE | 10 | | @BUF 1:00 | | 156 | 2 | | 29/35FG66/66XP | | 168.9 | 10.6 | | 9.67 | 9.3 | | Locked | Starting K | | New York Jets | TM | NYJ | 10 | | TB 1:00 | | 300 | 21 | | 2TD11INT30Sack3TD | | 266 | 16.6 | | 15.67 | 19.2 | | Locked | Starting TM | | Benched |
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| Ryan Fitzpatrick | QB | TEN | 8 | | @PIT 1:00 | | 487 | 20 | | 3,400Yd25TD | | 555.4 | 34.7 | | 31.67 | 32.46 | | Locked | Benched | | John Skelton | QB | CIN | 12 | | @CHI 1:00 | | 513 | 38 | | 1,132Yd2TD | | 122 | 17.4 | | 12.73 | 21 | | Locked | Benched | | Donald Brown | RB | IND | 8 | | OAK 1:00 | | 312 | 60 | | 510Yd1TD | | 68 | 6.8 | | 4.83↓ | 4.08↓ | | Locked | Benched | | James Starks | RB | GB | 4 | | @SF 4:25 | | 344 | 87 | | 286Yd1TD | | 38.6 | 6.4 | | 9.57 | 7.5 | | Locked | Benched | | Sidney Rice | WR | SEA | 12 | | @CAR 1:00 | | 141 | 36 | | 754Yd7TD | | 174.5 | 10.9 | | 4.67 | 8.28 | | Locked | Benched | | Greg Jennings | WR | MIN | 5 | | @DET 1:00 | | 89 | 76 | | 366Yd4TD | | 96.6 | 12.1 | | 19.5 | 14.16 | | Locked | Benched | | Heath Miller | TE | PIT | 5 | | TEN 1:00 | | 276 | 4 | | 816Yd8TD | | 203.6 | 13.6 | | 14.1 | 15.06 | | Locked | Benched | | Matt Prater | K | DEN | 9 | | BAL 8:30 | | 157 | 10 | | 26/32FG55/55XP | | 142.9 | 8.9 | | 9.97 | 10.4 | | Locked | Benched | | Detroit Lions | TM | DET | 9 | | MIN 1:00 | | 400 | 28 | | 11INT34Sack | | 222 | 13.9 | | 8.33↓ | 11.2 | | Locked | Benched |
| | Record | | | Points | | | Rank | | | Owner | Take Over | | Last Lineup Change | 11/16/2008 | | Previous | L  @THE LAW | | Current | @Old S... | | Roster | 3 QB 3-3 4 RB 4-4 4 WR 4-5 2 TE 2-2 2 K 2-2 2 TM 2-2 |
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