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| Player | | Opp | | Rank | | 2012 Stats | | Fantasy | | Pts in Last | | Availability |
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| Name | Pos | Team | Bye | | | | Draft | Pos | | Summary | | Total | Avg | | 3 | 5 | | Owner | % Own | Action |
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| C. J. Spiller | RB | BUF | 12 | | NE 1:00 | | 5 | 8 | | 1,703Yd8TD | | 219.3 | 13.7 | | 17.5↑ | 14.82 | | | | Locked | | Trent Richardson | RB | CLE | 10 | | MIA 1:00 | | 9 | 9 | | 1,317Yd12TD | | 201.7 | 13.4 | | 13.03 | 14.36 | | | | Locked | | Doug Martin | RB | TB | 5 | | @NYJ 1:00 | | 13 | 2 | | 1,926Yd12TD | | 273.6 | 17.1 | | 13.13 | 13.68 | | | | Locked | | Alfred Morris | RB | WAS | 5 | | PHI 7:10 | | 20 | 5 | | 1,690Yd13TD | | 242.3 | 15.1 | | 26.77↑ | 21.38 | | | | Locked | | Demaryius Thomas | WR | DEN | 9 | | BAL 8:30 | | 21 | 5 | | 1,434Yd10TD | | 207.2 | 12.9 | | 12.57 | 13.58 | | | | Locked | | Peyton Manning | QB | DEN | 9 | | BAL 8:30 | | 30 | 5 | | 4,659Yd37TD | | 389.05 | 24.3 | | 24.78 | 23.63 | | | | Locked | | Colin Kaepernick | QB | SF | 9 | | GB 4:25 | | 33 | 26 | | 1,814Yd15TD | | 189.15 | 14.6 | | 21.73↑ | 20.71↑ | | | | Locked | | Stevan Ridley | RB | NE | 10 | | @BUF 1:00 | | 48 | 11 | | 1,314Yd12TD | | 198.4 | 12.4 | | 9.37 | 10.68 | | | | Locked | | Randall Cobb | WR | GB | 4 | | @SF 4:25 | | 51 | 17 | | 1,086Yd9TD | | 161.6 | 10.8 | | 10.63 | 8.74 | | | | Locked | | Andrew Luck | QB | IND | 8 | | OAK 1:00 | | 56 | 10 | | 4,374Yd28TD | | 339.2 | 21.2 | | 18.77 | 20.13 | | | | Locked | | Chris Ivory | RB | NYJ | 10 | | TB 1:00 | | 60 | 72 | | 232Yd2TD | | 37.2 | 6.2 | | 2↓ | 5.24 | | | | Locked | | David Wilson | RB | NYG | 9 | | @DAL 8:30 | | 59 | 44 | | 392Yd6TD | | 77.2 | 4.8 | | 9.77↑ | 12.04 | | | | Locked | | Robert Griffin | QB | WAS | 5 | | PHI 7:10 | | 65 | 8 | | 3,200Yd27TD | | 362.85 | 24.2 | | 17.1↓ | 21.42 | | | | Locked | | Danny Amendola | WR | NE | 10 | | @BUF 1:00 | | 67 | 55 | | 674Yd3TD | | 87.4 | 7.9 | | 4.67 | 4.38 | | | | Locked | | Kyle Rudolph | TE | MIN | 5 | | @DET 1:00 | | 72 | 10 | | 493Yd9TD | | 105.3 | 6.6 | | 4.7 | 5.04 | | | | Locked | | Russell Wilson | QB | SEA | 12 | | @CAR 1:00 | | 74 | 12 | | 3,118Yd30TD | | 309.8 | 19.4 | | 31.4↑ | 26.91 | | | | Locked | | Dennis Pitta | TE | BAL | 8 | | @DEN 8:30 | | 76 | 7 | | 669Yd7TD | | 110.9 | 6.9 | | 10.7 | 8.92 | | | | Locked | | Lamar Miller | RB | MIA | 6 | | @CLE 1:00 | | 62 | 73 | | 295Yd1TD | | 35.5 | 3.9 | | 4.27 | 3.24 | | | | Locked | | Fred Jackson | RB | BUF | 12 | | NE 1:00 | | 79 | 42 | | 654Yd4TD | | 80.4 | 8 | | 5.1 | 7.86 | | | | Locked | | Cecil Shorts | WR | JAC | 9 | | KC 1:00 | | 81 | 19 | | 975Yd7TD | | 147.5 | 10.5 | | 9.73 | 12.76 | | | | Locked | |
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